tetano
Editor, Senior Moderator
Int J Cardiovasc Imaging
. 2021 Jun 23.
doi: 10.1007/s10554-021-02317-w. Online ahead of print.
Transient left ventricular clot in COVID-19-related myocarditis is associated with hypereosinophilic syndrome: a case report
Naghmeh Ziaie[SUP] #[/SUP][SUP] 1 2 [/SUP], Parviz Amri Maleh[SUP] 3 [/SUP], Mohammad Mostafa Ansari Ramandi[SUP] 4 [/SUP], Roghayeh Pourkia[SUP] 5 6 [/SUP], Kayvan Latifi[SUP] 7 [/SUP], Davood Mansouri[SUP] #[/SUP][SUP] 8 9 10 11 [/SUP]
Affiliations
Abstract
Frequent clinical presentations have been reported in patients with Coronavirus disease 2019 (COVID-19). It may be associated with multi-organ and cardiovascular involvements such as myocarditis and clot formation. Hypereosinophilic syndrome (HES) is a rare disease diagnosed with idiopathic eosinophilia and organ involvement. Here, we report a patient with COVID-19 who presented with clot formation and myocarditis. One month after discharge, regarding persistent peripheral/bone marrow hypereosinophilia and clot in echocardiography, fluorescent in situ hybridization (FISH) analysis was done that showed FIP1L1-CHIC2 fusion (PDGFRɑ rearrangement) in 18% of scored cells and PDGFRβ rearrangement in 12% of scored cells, which confirmed HES diagnosis. Clot formation may be a late manifestation of COVID-19 or myocarditis due to COVID-19, or the first manifestation of HES that COVID-19 might provoke in this rare syndrome.
Keywords: COVID-19; Case report; Coronavirus; Hypereosinophilic syndrome; Left ventricular clot.
. 2021 Jun 23.
doi: 10.1007/s10554-021-02317-w. Online ahead of print.
Transient left ventricular clot in COVID-19-related myocarditis is associated with hypereosinophilic syndrome: a case report
Naghmeh Ziaie[SUP] #[/SUP][SUP] 1 2 [/SUP], Parviz Amri Maleh[SUP] 3 [/SUP], Mohammad Mostafa Ansari Ramandi[SUP] 4 [/SUP], Roghayeh Pourkia[SUP] 5 6 [/SUP], Kayvan Latifi[SUP] 7 [/SUP], Davood Mansouri[SUP] #[/SUP][SUP] 8 9 10 11 [/SUP]
Affiliations
- PMID: 34160722
- DOI: 10.1007/s10554-021-02317-w
Abstract
Frequent clinical presentations have been reported in patients with Coronavirus disease 2019 (COVID-19). It may be associated with multi-organ and cardiovascular involvements such as myocarditis and clot formation. Hypereosinophilic syndrome (HES) is a rare disease diagnosed with idiopathic eosinophilia and organ involvement. Here, we report a patient with COVID-19 who presented with clot formation and myocarditis. One month after discharge, regarding persistent peripheral/bone marrow hypereosinophilia and clot in echocardiography, fluorescent in situ hybridization (FISH) analysis was done that showed FIP1L1-CHIC2 fusion (PDGFRɑ rearrangement) in 18% of scored cells and PDGFRβ rearrangement in 12% of scored cells, which confirmed HES diagnosis. Clot formation may be a late manifestation of COVID-19 or myocarditis due to COVID-19, or the first manifestation of HES that COVID-19 might provoke in this rare syndrome.
Keywords: COVID-19; Case report; Coronavirus; Hypereosinophilic syndrome; Left ventricular clot.