tetano
Editor, Senior Moderator
Int J Cardiovasc Imaging
. 2022 Aug 13.
doi: 10.1007/s10554-022-02706-9. Online ahead of print.
Abnormal echocardiographic findings after COVID-19 infection: a multicenter registry
Sebastián Garcia-Zamora[SUP] 1 [/SUP], José M Picco[SUP] 2 [/SUP], Augusto J Lepori[SUP] 3 [/SUP], Marcela I Galello[SUP] 4 [/SUP], Ariel K Saad[SUP] 5 [/SUP], Miguel Ayón[SUP] 6 [/SUP], Nancy Monga-Aguilar[SUP] 7 [/SUP], Issam Shehadeh[SUP] 8 [/SUP], Carlos F Manganiello[SUP] 9 [/SUP], Cintia Izaguirre[SUP] 10 [/SUP], Luciano N Fallabrino[SUP] 11 [/SUP], Matias Clavero[SUP] 12 [/SUP], Flavia Mansur[SUP] 5 [/SUP], Sebastián Ghibaudo[SUP] 13 [/SUP], Daniela Sevilla[SUP] 5 10 [/SUP], Cesar A Cado[SUP] 6 [/SUP], Mauricio Priotti[SUP] 14 [/SUP], Kiera Liblik[SUP] 15 [/SUP], Natalio Gastaldello[SUP] 5 7 [/SUP], Pablo M Merlo[SUP] 5 7 [/SUP]
Affiliations
Abstract
The Coronavirus Disease 2019 (COVID-19) pandemic has transformed health systems worldwide. There is conflicting data regarding the degree of cardiovascular involvement following infection. A registry was designed to evaluate the prevalence of echocardiographic abnormalities in adults recovered from COVID-19. We prospectively evaluated 595 participants (mean age 45.5 ± 14.9 years; 50.8% female) from 10 institutions in Argentina and Brazil. Median time between infection and evaluation was two months, and 82.5% of participants were not hospitalized for their infection. Echocardiographic studies were conducted with General Electric equipment; 2DE imaging and global longitudinal strain (GLS) of both ventricles were performed. A total of 61.7% of the participants denied relevant cardiovascular history and 41.8% had prolonged symptoms after resolution of COVID-19 infection. Mean left ventricular ejection fraction (LVEF) was 61.0 ± 5.5% overall. In patients without prior comorbidities, 8.2% had some echocardiographic abnormality: 5.7% had reduced GLS, 3.0% had a LVEF below normal range, and 1.1% had wall motion abnormalities. The right ventricle (RV) was dilated in 1.6% of participants, 3.1% had a reduced GLS, and 0.27% had reduced RV function. Mild pericardial effusion was observed in 0.82% of participants. Male patients were more likely to have new echocardiographic abnormalities (OR 2.82, p = 0.002). Time elapsed since infection resolution (p = 0.245), presence of symptoms (p = 0.927), or history of hospitalization during infection (p = 0.671) did not have any correlation with echocardiographic abnormalities. Cardiovascular abnormalities after COVID-19 infection are rare and usually mild, especially following mild infection, being a low GLS of left and right ventricle, the most common ones in our registry. Post COVID cardiac abnormalities may be more frequent among males.
Keywords: COVID-19; Diagnostic imaging; Echocardiography; Humans; Myocarditis; Ventricular remodeling.
. 2022 Aug 13.
doi: 10.1007/s10554-022-02706-9. Online ahead of print.
Abnormal echocardiographic findings after COVID-19 infection: a multicenter registry
Sebastián Garcia-Zamora[SUP] 1 [/SUP], José M Picco[SUP] 2 [/SUP], Augusto J Lepori[SUP] 3 [/SUP], Marcela I Galello[SUP] 4 [/SUP], Ariel K Saad[SUP] 5 [/SUP], Miguel Ayón[SUP] 6 [/SUP], Nancy Monga-Aguilar[SUP] 7 [/SUP], Issam Shehadeh[SUP] 8 [/SUP], Carlos F Manganiello[SUP] 9 [/SUP], Cintia Izaguirre[SUP] 10 [/SUP], Luciano N Fallabrino[SUP] 11 [/SUP], Matias Clavero[SUP] 12 [/SUP], Flavia Mansur[SUP] 5 [/SUP], Sebastián Ghibaudo[SUP] 13 [/SUP], Daniela Sevilla[SUP] 5 10 [/SUP], Cesar A Cado[SUP] 6 [/SUP], Mauricio Priotti[SUP] 14 [/SUP], Kiera Liblik[SUP] 15 [/SUP], Natalio Gastaldello[SUP] 5 7 [/SUP], Pablo M Merlo[SUP] 5 7 [/SUP]
Affiliations
- PMID: 36515755
- DOI: 10.1007/s10554-022-02706-9
Abstract
The Coronavirus Disease 2019 (COVID-19) pandemic has transformed health systems worldwide. There is conflicting data regarding the degree of cardiovascular involvement following infection. A registry was designed to evaluate the prevalence of echocardiographic abnormalities in adults recovered from COVID-19. We prospectively evaluated 595 participants (mean age 45.5 ± 14.9 years; 50.8% female) from 10 institutions in Argentina and Brazil. Median time between infection and evaluation was two months, and 82.5% of participants were not hospitalized for their infection. Echocardiographic studies were conducted with General Electric equipment; 2DE imaging and global longitudinal strain (GLS) of both ventricles were performed. A total of 61.7% of the participants denied relevant cardiovascular history and 41.8% had prolonged symptoms after resolution of COVID-19 infection. Mean left ventricular ejection fraction (LVEF) was 61.0 ± 5.5% overall. In patients without prior comorbidities, 8.2% had some echocardiographic abnormality: 5.7% had reduced GLS, 3.0% had a LVEF below normal range, and 1.1% had wall motion abnormalities. The right ventricle (RV) was dilated in 1.6% of participants, 3.1% had a reduced GLS, and 0.27% had reduced RV function. Mild pericardial effusion was observed in 0.82% of participants. Male patients were more likely to have new echocardiographic abnormalities (OR 2.82, p = 0.002). Time elapsed since infection resolution (p = 0.245), presence of symptoms (p = 0.927), or history of hospitalization during infection (p = 0.671) did not have any correlation with echocardiographic abnormalities. Cardiovascular abnormalities after COVID-19 infection are rare and usually mild, especially following mild infection, being a low GLS of left and right ventricle, the most common ones in our registry. Post COVID cardiac abnormalities may be more frequent among males.
Keywords: COVID-19; Diagnostic imaging; Echocardiography; Humans; Myocarditis; Ventricular remodeling.