tetano
Editor, Senior Moderator
Int J Cardiol Heart Vasc
. 2020 Sep 12;30:100638.
doi: 10.1016/j.ijcha.2020.100638. Online ahead of print.
? IMPLICATIONS OF MYOCARDIAL INJURY IN MEXICAN HOSPITALIZED PATIENTS WITH CORONAVIRUS DISEASE 2019 (COVID-19)
Aquino Bruno Heberto[SUP] 1 [/SUP], Plata Corona Juan Carlos[SUP] 2 [/SUP], Castro Rubio Jos? Antonio[SUP] 3 [/SUP], Pulido P?rez Patricia[SUP] 2 [/SUP], Torres Rasgado Enrique[SUP] 2 [/SUP], Morales Portano Julieta Danira[SUP] 1 [/SUP], G?mez ?lvarez Enrique Benito[SUP] 1 [/SUP], Merino Rajme Jos? Alfredo[SUP] 1 [/SUP]
Affiliations
Abstract
Background: Respiratory illnesses is the most common manifestation of Coronavirus disease 2019 (COVID-19); however, myocardial injury has recently emerged as a frequent complication.
Methods: An observational, longitudinal, prospective, and multicenter study of hospitalized Mexican patients was made. We assessed the prevalence of myocardial injury and its relationship with complications and mortality.
Results: 254 COVID-19 patients were included. Their average age was 53.8 years old, 167 (65.7%) were male and 87 (34.3%) female. According to troponin levels, two populations were generated, those with and without myocardial injury. There was no difference in gender or age between both groups. However, there was a greater proportion of obesity and hypertension in myocardial injury group. Multivariate logistic regression analysis revealed that obesity (OR 2.029, 95% CI 1.039-3.961; p=0.038), arterial oxygen saturation <90% (OR 2.250, 95% CI 1.216-3.560; p=0.025), and systolic blood pressure <90 mmHg (OR 2.636, 95% CI 1.530-4.343; p=0.042), were directly related to higher levels of troponins. Multivariate cox proportional hazards analysis showed that primary endpoint (mortality) was determined by overweight/obesity (OR 1.290, 95% CI 0.115-0.730; p=0.009), ferritin levels (OR 1.001, 95% CI 1.000-1.001; p<0.001), myocardial injury (OR 3.764, 95% CI 1.307-10.838; p=0.014), septic shock (OR 4.104, 95% CI 1.142-14.132; p=0.024), acute respiratory distress syndrome (OR 3.001, 95% CI 1.008-10.165; p=0.040), and treatment with Hydroxychloroquine/Azithromycin (OR 0.357, 95% IC 0.133-0.955; p=0.040) .Secondary endpoint (Mechanical ventilation risk) was associated to the same factors.
Conclusions: Myocardial injury represents an increased risk of complications and death in Mexican hospitalized patients with COVID-19.
Keywords: COVID-19; Coronavirus; SARS-CoV-2; myocardial injury; troponins.
. 2020 Sep 12;30:100638.
doi: 10.1016/j.ijcha.2020.100638. Online ahead of print.
? IMPLICATIONS OF MYOCARDIAL INJURY IN MEXICAN HOSPITALIZED PATIENTS WITH CORONAVIRUS DISEASE 2019 (COVID-19)
Aquino Bruno Heberto[SUP] 1 [/SUP], Plata Corona Juan Carlos[SUP] 2 [/SUP], Castro Rubio Jos? Antonio[SUP] 3 [/SUP], Pulido P?rez Patricia[SUP] 2 [/SUP], Torres Rasgado Enrique[SUP] 2 [/SUP], Morales Portano Julieta Danira[SUP] 1 [/SUP], G?mez ?lvarez Enrique Benito[SUP] 1 [/SUP], Merino Rajme Jos? Alfredo[SUP] 1 [/SUP]
Affiliations
- PMID: 32953968
- PMCID: PMC7486879
- DOI: 10.1016/j.ijcha.2020.100638
Abstract
Background: Respiratory illnesses is the most common manifestation of Coronavirus disease 2019 (COVID-19); however, myocardial injury has recently emerged as a frequent complication.
Methods: An observational, longitudinal, prospective, and multicenter study of hospitalized Mexican patients was made. We assessed the prevalence of myocardial injury and its relationship with complications and mortality.
Results: 254 COVID-19 patients were included. Their average age was 53.8 years old, 167 (65.7%) were male and 87 (34.3%) female. According to troponin levels, two populations were generated, those with and without myocardial injury. There was no difference in gender or age between both groups. However, there was a greater proportion of obesity and hypertension in myocardial injury group. Multivariate logistic regression analysis revealed that obesity (OR 2.029, 95% CI 1.039-3.961; p=0.038), arterial oxygen saturation <90% (OR 2.250, 95% CI 1.216-3.560; p=0.025), and systolic blood pressure <90 mmHg (OR 2.636, 95% CI 1.530-4.343; p=0.042), were directly related to higher levels of troponins. Multivariate cox proportional hazards analysis showed that primary endpoint (mortality) was determined by overweight/obesity (OR 1.290, 95% CI 0.115-0.730; p=0.009), ferritin levels (OR 1.001, 95% CI 1.000-1.001; p<0.001), myocardial injury (OR 3.764, 95% CI 1.307-10.838; p=0.014), septic shock (OR 4.104, 95% CI 1.142-14.132; p=0.024), acute respiratory distress syndrome (OR 3.001, 95% CI 1.008-10.165; p=0.040), and treatment with Hydroxychloroquine/Azithromycin (OR 0.357, 95% IC 0.133-0.955; p=0.040) .Secondary endpoint (Mechanical ventilation risk) was associated to the same factors.
Conclusions: Myocardial injury represents an increased risk of complications and death in Mexican hospitalized patients with COVID-19.
Keywords: COVID-19; Coronavirus; SARS-CoV-2; myocardial injury; troponins.