tetano
Editor, Senior Moderator
Int J Cancer
. 2020 Dec 3.
doi: 10.1002/ijc.33420. Online ahead of print.
A snapshot of COVID-19 infection in patients with solid tumors
Jes?s Fuentes-Antr?s[SUP] 1 [/SUP], Ar?nzazu Manzano[SUP] 1 2 [/SUP], Gloria Marquina[SUP] 1 [/SUP], Mateo Paz[SUP] 1 3 [/SUP], Carlos Aguado[SUP] 1 [/SUP], M?nica Granja[SUP] 1 [/SUP], Javier Ben?tez[SUP] 1 [/SUP], Justo Ortega[SUP] 1 [/SUP], Araceli Priego[SUP] 1 [/SUP], Carlos Gonz?lez[SUP] 1 [/SUP], Julia Tejerina-Peces[SUP] 1 [/SUP], Paloma Flores[SUP] 1 [/SUP], Alfonso L?pez de Sa[SUP] 1 [/SUP], Carmen Toledano[SUP] 1 [/SUP], Jennifer Olalla[SUP] 1 [/SUP], Alicia de Luna[SUP] 1 [/SUP], Jorge Bartolom?[SUP] 1 [/SUP], Pedro P?rez-Segura[SUP] 1 [/SUP]
Affiliations
Abstract
Coronavirus disease 2019 (COVID-19) pandemic is affecting a high percentage of the population at an unprecedented rate. Cancer patients comprise a subgroup especially vulnerable to this infection. Herein, we present a prospective analysis of epidemiological, clinical, radiological and laboratory data of consecutive adult cancer patients seen in the Cl?nico San Carlos University Hospital (Madrid, Spain), and admitted to hospital and tested for COVID-19 between February 21 and May 8, 2020 due to clinical suspicion of infection. Data from 73 patients with confirmed COVID-19 and active solid tumors or diagnosed within the previous 5 years were analyzed. The most frequent malignancy was lung cancer (19%) and 54 patients (74%) were on active cancer treatment. Most common findings on presentation included cough (55%), fever (52%), and dyspnea (45%), and 32 (44%) patients showed oxygen saturation levels below 95%. Radiologically, 54 (73%) patients presented an abnormal pattern, the most frequent being infiltrates (64%). 18 (24.7%) patients died in hospital and 55 (75.3%) were discharged with clinical resolution of the event. Multivariable logistic regression adjusted for age and tumor stage showed higher odds of in-hospital death associated with a history of cardiovascular disease, hospitalization in the previous 30 days, and several features on admission including dyspnea, higher qSOFA score, higher C-reactive protein levels, and an abnormal neutrophil count. We present prospective, real-world evidence that can help articulate cancer care protocols for patients infected with SARS-CoV-2, with special focus on features on admission that can stratify patients with a higher risk of death from COVID-19.
. 2020 Dec 3.
doi: 10.1002/ijc.33420. Online ahead of print.
A snapshot of COVID-19 infection in patients with solid tumors
Jes?s Fuentes-Antr?s[SUP] 1 [/SUP], Ar?nzazu Manzano[SUP] 1 2 [/SUP], Gloria Marquina[SUP] 1 [/SUP], Mateo Paz[SUP] 1 3 [/SUP], Carlos Aguado[SUP] 1 [/SUP], M?nica Granja[SUP] 1 [/SUP], Javier Ben?tez[SUP] 1 [/SUP], Justo Ortega[SUP] 1 [/SUP], Araceli Priego[SUP] 1 [/SUP], Carlos Gonz?lez[SUP] 1 [/SUP], Julia Tejerina-Peces[SUP] 1 [/SUP], Paloma Flores[SUP] 1 [/SUP], Alfonso L?pez de Sa[SUP] 1 [/SUP], Carmen Toledano[SUP] 1 [/SUP], Jennifer Olalla[SUP] 1 [/SUP], Alicia de Luna[SUP] 1 [/SUP], Jorge Bartolom?[SUP] 1 [/SUP], Pedro P?rez-Segura[SUP] 1 [/SUP]
Affiliations
- PMID: 33270902
- DOI: 10.1002/ijc.33420
Abstract
Coronavirus disease 2019 (COVID-19) pandemic is affecting a high percentage of the population at an unprecedented rate. Cancer patients comprise a subgroup especially vulnerable to this infection. Herein, we present a prospective analysis of epidemiological, clinical, radiological and laboratory data of consecutive adult cancer patients seen in the Cl?nico San Carlos University Hospital (Madrid, Spain), and admitted to hospital and tested for COVID-19 between February 21 and May 8, 2020 due to clinical suspicion of infection. Data from 73 patients with confirmed COVID-19 and active solid tumors or diagnosed within the previous 5 years were analyzed. The most frequent malignancy was lung cancer (19%) and 54 patients (74%) were on active cancer treatment. Most common findings on presentation included cough (55%), fever (52%), and dyspnea (45%), and 32 (44%) patients showed oxygen saturation levels below 95%. Radiologically, 54 (73%) patients presented an abnormal pattern, the most frequent being infiltrates (64%). 18 (24.7%) patients died in hospital and 55 (75.3%) were discharged with clinical resolution of the event. Multivariable logistic regression adjusted for age and tumor stage showed higher odds of in-hospital death associated with a history of cardiovascular disease, hospitalization in the previous 30 days, and several features on admission including dyspnea, higher qSOFA score, higher C-reactive protein levels, and an abnormal neutrophil count. We present prospective, real-world evidence that can help articulate cancer care protocols for patients infected with SARS-CoV-2, with special focus on features on admission that can stratify patients with a higher risk of death from COVID-19.