tetano
Editor, Senior Moderator
Int J Biol Sci
. 2022 Jan 1;18(3):901-910.
doi: 10.7150/ijbs.64993. eCollection 2022.
Human Organoids as a Promising Platform for Fighting COVID-19
Dong Chen[SUP] 1 [/SUP], Xi Su[SUP] 1 [/SUP], Haibo Chen[SUP] 2 [/SUP], Siyan Chen[SUP] 3 [/SUP], Yongsheng Zhao[SUP] 2 [/SUP], Wei Wei[SUP] 1 [/SUP]
Affiliations
Abstract
The coronavirus disease 2019 (COVID-19) global pandemic evoked by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has triggered a major public health problem with significant morbidity and mortality. Understanding the pathogenesis and molecular mechanisms underlying this novel virus is crucial for both fundamental research and clinical trials in order to devise effective therapies and vaccination regimens. Basic research on SARS-CoV-2 largely depends on ex vivo models that allow viral invasion and replication. Organoid models are now emerging as a valuable tool to investigate viral biology and disease progression, serving as an efficient platform to investigate potential therapies for COVID-19. Here, we summarize various human stem cell-derived organoid types employed in SARS-CoV-2 studies. We highlight key findings from these models, including cell tropisms and molecular mechanisms in viral infection. We also describe their use in identifying potential therapeutic agents against SARS-CoV-2. As more and more advanced organoids emerge, they will facilitate the understanding of disease pathogenesis for drug development in this dreaded pandemic.
Keywords: COVID-19; SARS-CoV-2; drug screening; infection; organoid.
. 2022 Jan 1;18(3):901-910.
doi: 10.7150/ijbs.64993. eCollection 2022.
Human Organoids as a Promising Platform for Fighting COVID-19
Dong Chen[SUP] 1 [/SUP], Xi Su[SUP] 1 [/SUP], Haibo Chen[SUP] 2 [/SUP], Siyan Chen[SUP] 3 [/SUP], Yongsheng Zhao[SUP] 2 [/SUP], Wei Wei[SUP] 1 [/SUP]
Affiliations
- PMID: 35173525
- PMCID: PMC8771829
- DOI: 10.7150/ijbs.64993
Abstract
The coronavirus disease 2019 (COVID-19) global pandemic evoked by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has triggered a major public health problem with significant morbidity and mortality. Understanding the pathogenesis and molecular mechanisms underlying this novel virus is crucial for both fundamental research and clinical trials in order to devise effective therapies and vaccination regimens. Basic research on SARS-CoV-2 largely depends on ex vivo models that allow viral invasion and replication. Organoid models are now emerging as a valuable tool to investigate viral biology and disease progression, serving as an efficient platform to investigate potential therapies for COVID-19. Here, we summarize various human stem cell-derived organoid types employed in SARS-CoV-2 studies. We highlight key findings from these models, including cell tropisms and molecular mechanisms in viral infection. We also describe their use in identifying potential therapeutic agents against SARS-CoV-2. As more and more advanced organoids emerge, they will facilitate the understanding of disease pathogenesis for drug development in this dreaded pandemic.
Keywords: COVID-19; SARS-CoV-2; drug screening; infection; organoid.