tetano
Editor, Senior Moderator
Int J Biol Macromol
. 2021 Dec 1;S0141-8130(21)02556-3.
doi: 10.1016/j.ijbiomac.2021.11.151. Online ahead of print.
Emergence of unique SARS-CoV-2 ORF10 variants and their impact on protein structure and function
Sk Sarif Hassan[SUP] 1 [/SUP], Kenneth Lundstrom[SUP] 2 [/SUP], Ángel Serrano-Aroca[SUP] 3 [/SUP], Parise Adadi[SUP] 4 [/SUP], Alaa A A Aljabali[SUP] 5 [/SUP], Elrashdy M Redwan[SUP] 6 [/SUP], Amos Lal[SUP] 7 [/SUP], Ramesh Kandimalla[SUP] 8 [/SUP], Tarek Mohamed Abd El-Aziz[SUP] 9 [/SUP], Pabitra Pal Choudhury[SUP] 10 [/SUP], Gajendra Kumar Azad[SUP] 11 [/SUP], Samendra P Sherchan[SUP] 12 [/SUP], Gaurav Chauhan[SUP] 13 [/SUP], Murtaza Tambuwala[SUP] 14 [/SUP], Kazuo Takayama[SUP] 15 [/SUP], Debmalya Barh[SUP] 16 [/SUP], Giorgio Palu[SUP] 17 [/SUP], Pallab Basu[SUP] 18 [/SUP], Vladimir N Uversky[SUP] 19 [/SUP]
Affiliations
Abstract
The devastating impact of the ongoing coronavirus disease 2019 (COVID-19) on public health, caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has made targeting the COVID-19 pandemic a top priority in medical research and pharmaceutical development. Surveillance of SARS-CoV-2 mutations is essential for the comprehension of SARS-CoV-2 variant diversity and their impact on virulence and pathogenicity. The SARS-CoV-2 open reading frame 10 (ORF10) protein interacts with multiple human proteins CUL2, ELOB, ELOC, MAP7D1, PPT1, RBX1, THTPA, TIMM8B, and ZYG11B expressed in lung tissue. Mutations and co-occurring mutations in the emerging SARS-CoV-2 ORF10 variants are expected to impact the severity of the virus and its associated consequences. In this article, we highlight 128 single mutations and 35 co-occurring mutations in the unique SARS-CoV-2 ORF10 variants. The possible predicted effects of these mutations and co-occurring mutations on the secondary structure of ORF10 variants and host protein interactomes are presented. The findings highlight the possible effects of mutations and co-occurring mutations on the emerging 140 ORF10 unique variants from secondary structure and intrinsic protein disorder perspectives.
Keywords: And ubiquitin ligase complex; Co-occurring mutations; Intrinsic protein disorder; ORF10; SARS-CoV-2.
. 2021 Dec 1;S0141-8130(21)02556-3.
doi: 10.1016/j.ijbiomac.2021.11.151. Online ahead of print.
Emergence of unique SARS-CoV-2 ORF10 variants and their impact on protein structure and function
Sk Sarif Hassan[SUP] 1 [/SUP], Kenneth Lundstrom[SUP] 2 [/SUP], Ángel Serrano-Aroca[SUP] 3 [/SUP], Parise Adadi[SUP] 4 [/SUP], Alaa A A Aljabali[SUP] 5 [/SUP], Elrashdy M Redwan[SUP] 6 [/SUP], Amos Lal[SUP] 7 [/SUP], Ramesh Kandimalla[SUP] 8 [/SUP], Tarek Mohamed Abd El-Aziz[SUP] 9 [/SUP], Pabitra Pal Choudhury[SUP] 10 [/SUP], Gajendra Kumar Azad[SUP] 11 [/SUP], Samendra P Sherchan[SUP] 12 [/SUP], Gaurav Chauhan[SUP] 13 [/SUP], Murtaza Tambuwala[SUP] 14 [/SUP], Kazuo Takayama[SUP] 15 [/SUP], Debmalya Barh[SUP] 16 [/SUP], Giorgio Palu[SUP] 17 [/SUP], Pallab Basu[SUP] 18 [/SUP], Vladimir N Uversky[SUP] 19 [/SUP]
Affiliations
- PMID: 34863825
- DOI: 10.1016/j.ijbiomac.2021.11.151
Abstract
The devastating impact of the ongoing coronavirus disease 2019 (COVID-19) on public health, caused by the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) has made targeting the COVID-19 pandemic a top priority in medical research and pharmaceutical development. Surveillance of SARS-CoV-2 mutations is essential for the comprehension of SARS-CoV-2 variant diversity and their impact on virulence and pathogenicity. The SARS-CoV-2 open reading frame 10 (ORF10) protein interacts with multiple human proteins CUL2, ELOB, ELOC, MAP7D1, PPT1, RBX1, THTPA, TIMM8B, and ZYG11B expressed in lung tissue. Mutations and co-occurring mutations in the emerging SARS-CoV-2 ORF10 variants are expected to impact the severity of the virus and its associated consequences. In this article, we highlight 128 single mutations and 35 co-occurring mutations in the unique SARS-CoV-2 ORF10 variants. The possible predicted effects of these mutations and co-occurring mutations on the secondary structure of ORF10 variants and host protein interactomes are presented. The findings highlight the possible effects of mutations and co-occurring mutations on the emerging 140 ORF10 unique variants from secondary structure and intrinsic protein disorder perspectives.
Keywords: And ubiquitin ligase complex; Co-occurring mutations; Intrinsic protein disorder; ORF10; SARS-CoV-2.