tetano
Editor, Senior Moderator
Int J Biol Macromol
. 2020 Jul 14;S0141-8130(20)33869-1.
doi: 10.1016/j.ijbiomac.2020.07.106. Online ahead of print.
Application prospect of polysaccharides in the development of anti-novel coronavirus drugs and vaccines
Xiangyan Chen[SUP] 1 [/SUP], Wenwei Han[SUP] 1 [/SUP], Guixiang Wang[SUP] 2 [/SUP], Xia Zhao[SUP] 3 [/SUP]
Affiliations
Abstract
Since the outbreak of the novel coronavirus disease COVID-19, caused by the SARS-CoV-2 virus, it has spread rapidly worldwide and poses a great threat to public health. This is the third serious coronavirus outbreak in <20 years, following SARS in 2002-2003 and MERS in 2012. So far, there are almost no specific clinically effective drugs and vaccines available for COVID-19. Polysaccharides with good safety, immune regulation and antiviral activity have broad application prospects in anti-virus, especially in anti-coronavirus applications. Here, we reviewed the antiviral mechanisms of some polysaccharides, such as glycosaminoglycans, marine polysaccharides, traditional Chinese medicine polysaccharides, and their application progress in anti-coronavirus. In particular, the application prospects of polysaccharide-based vaccine adjuvants, nanomaterials and drug delivery systems in the fight against novel coronavirus were also analyzed and summarized. Additionally, we speculate the possible mechanisms of polysaccharides anti-SARS-CoV-2, and propose the strategy of loading S or N protein from coronavirus onto polysaccharide capped gold nanoparticles vaccine for COVID-19 treatment. This review may provide a new approach for the development of COVID-19 therapeutic agents and vaccines.
Keywords: Antiviral activity; COVID-19; Coronavirus; Mechanism; Polysaccharides; SARS-CoV-2.
. 2020 Jul 14;S0141-8130(20)33869-1.
doi: 10.1016/j.ijbiomac.2020.07.106. Online ahead of print.
Application prospect of polysaccharides in the development of anti-novel coronavirus drugs and vaccines
Xiangyan Chen[SUP] 1 [/SUP], Wenwei Han[SUP] 1 [/SUP], Guixiang Wang[SUP] 2 [/SUP], Xia Zhao[SUP] 3 [/SUP]
Affiliations
- PMID: 32679328
- PMCID: PMC7358770
- DOI: 10.1016/j.ijbiomac.2020.07.106
Abstract
Since the outbreak of the novel coronavirus disease COVID-19, caused by the SARS-CoV-2 virus, it has spread rapidly worldwide and poses a great threat to public health. This is the third serious coronavirus outbreak in <20 years, following SARS in 2002-2003 and MERS in 2012. So far, there are almost no specific clinically effective drugs and vaccines available for COVID-19. Polysaccharides with good safety, immune regulation and antiviral activity have broad application prospects in anti-virus, especially in anti-coronavirus applications. Here, we reviewed the antiviral mechanisms of some polysaccharides, such as glycosaminoglycans, marine polysaccharides, traditional Chinese medicine polysaccharides, and their application progress in anti-coronavirus. In particular, the application prospects of polysaccharide-based vaccine adjuvants, nanomaterials and drug delivery systems in the fight against novel coronavirus were also analyzed and summarized. Additionally, we speculate the possible mechanisms of polysaccharides anti-SARS-CoV-2, and propose the strategy of loading S or N protein from coronavirus onto polysaccharide capped gold nanoparticles vaccine for COVID-19 treatment. This review may provide a new approach for the development of COVID-19 therapeutic agents and vaccines.
Keywords: Antiviral activity; COVID-19; Coronavirus; Mechanism; Polysaccharides; SARS-CoV-2.