tetano
Editor, Senior Moderator
Int J Antimicrob Agents
. 2022 Feb 5;106545.
doi: 10.1016/j.ijantimicag.2022.106545. Online ahead of print.
The effect of sofosbuvir-based treatment on the clinical outcomes of patients with COVID-19: a systematic review and meta-analysis of randomized controlled trials
Chi-Kuei Hsu[SUP] 1 [/SUP], Ching-Yi Chen[SUP] 2 [/SUP], Wang-Chun Chen[SUP] 3 [/SUP], Chih-Cheng Lai[SUP] 4 [/SUP], Shun-Hsing Hung[SUP] 5 [/SUP], Wei-Ting Lin[SUP] 6 [/SUP]
Affiliations
Abstract
Objective: This systematic review and meta-analysis examined the efficacy of sofosbuvir-based antiviral agents against coronavirus disease 2019 (COVID-19).
Methods: PubMed, Embase, Cochrane Central Register of Controlled Trials, and ClinicalTrials.gov were searched from inception to 15 August 2021. Studies comparing the clinical efficacy and safety of sofosbuvir-based antiviral regimens (study group) with other antivirals or standard of care (control group) in patients with COVID-19 were included.
Results: Overall, 687 patients with COVID-19 were included, of which 377 patients received sofosbuvir-based treatment. Mortality was lower in the study group than in the control group (odds ratio [OR], 0.49; 95% confidence interval [CI], 0.30-0.79; I[SUP]2[/SUP] = 0%). The overall clinical recovery rate was higher in the study group than in the control group (OR, 1.82; 95% CI, 1.20-2.76; I[SUP]2[/SUP] = 28%). The study group presented a lower requirement for mechanical ventilation (OR, 0.33; 95% CI, 0.13-0.89; I[SUP]2[/SUP] = 0%) and intensive care unit (ICU) admission (OR, 0.42; 95% CI, 0.25-0.70; I[SUP]2[/SUP] = 0%) than the control group. Furthermore, the study group exhibited a shorter length of hospital stay (mean deviation [MD], -1.49; 95% CI, -2.62 to -0.37, I[SUP]2[/SUP] = 56%) and recovery time (MD, -1.34; 95% CI, -2.29, -0.38, I[SUP]2[/SUP] = 46%) than the control group.
Conclusions: Sofosbuvir-based treatment may help reduce mortality in patients with COVID-19 and improve associated clinical outcomes. Furthermore, sofosbuvir-based treatment was as safe as the comparator in patients with COVID-19. However, further large-scale study is warranted to validate these findings.
Keywords: COVID-19; ICU; SARS-CoV-2; mortality; sofosbuvir.
. 2022 Feb 5;106545.
doi: 10.1016/j.ijantimicag.2022.106545. Online ahead of print.
The effect of sofosbuvir-based treatment on the clinical outcomes of patients with COVID-19: a systematic review and meta-analysis of randomized controlled trials
Chi-Kuei Hsu[SUP] 1 [/SUP], Ching-Yi Chen[SUP] 2 [/SUP], Wang-Chun Chen[SUP] 3 [/SUP], Chih-Cheng Lai[SUP] 4 [/SUP], Shun-Hsing Hung[SUP] 5 [/SUP], Wei-Ting Lin[SUP] 6 [/SUP]
Affiliations
- PMID: 35134505
- PMCID: PMC8817946
- DOI: 10.1016/j.ijantimicag.2022.106545
Abstract
Objective: This systematic review and meta-analysis examined the efficacy of sofosbuvir-based antiviral agents against coronavirus disease 2019 (COVID-19).
Methods: PubMed, Embase, Cochrane Central Register of Controlled Trials, and ClinicalTrials.gov were searched from inception to 15 August 2021. Studies comparing the clinical efficacy and safety of sofosbuvir-based antiviral regimens (study group) with other antivirals or standard of care (control group) in patients with COVID-19 were included.
Results: Overall, 687 patients with COVID-19 were included, of which 377 patients received sofosbuvir-based treatment. Mortality was lower in the study group than in the control group (odds ratio [OR], 0.49; 95% confidence interval [CI], 0.30-0.79; I[SUP]2[/SUP] = 0%). The overall clinical recovery rate was higher in the study group than in the control group (OR, 1.82; 95% CI, 1.20-2.76; I[SUP]2[/SUP] = 28%). The study group presented a lower requirement for mechanical ventilation (OR, 0.33; 95% CI, 0.13-0.89; I[SUP]2[/SUP] = 0%) and intensive care unit (ICU) admission (OR, 0.42; 95% CI, 0.25-0.70; I[SUP]2[/SUP] = 0%) than the control group. Furthermore, the study group exhibited a shorter length of hospital stay (mean deviation [MD], -1.49; 95% CI, -2.62 to -0.37, I[SUP]2[/SUP] = 56%) and recovery time (MD, -1.34; 95% CI, -2.29, -0.38, I[SUP]2[/SUP] = 46%) than the control group.
Conclusions: Sofosbuvir-based treatment may help reduce mortality in patients with COVID-19 and improve associated clinical outcomes. Furthermore, sofosbuvir-based treatment was as safe as the comparator in patients with COVID-19. However, further large-scale study is warranted to validate these findings.
Keywords: COVID-19; ICU; SARS-CoV-2; mortality; sofosbuvir.