tetano
Editor, Senior Moderator
Int J Antimicrob Agents. 2020 Apr 16:105988. doi: 10.1016/j.ijantimicag.2020.105988. [Epub ahead of print]
Can post-exposure prophylaxis for COVID-19 be considered as one of outbreak response strategies in long-term care hospitals?
Lee SH[SUP]1[/SUP], Son H[SUP]2[/SUP], Peck KR[SUP]3[/SUP].
Author information
Abstract
With ongoing global outbreak of coronavirus disease 2019 (COVID-19), management of exposure events is a concern. Long-term care hospitals (LTCHs) are especially vulnerable to cluster outbreaks, since it is difficult to find facilities and healthcare personnel for their separate isolation care in a large outbreak situation. Although several drugs have been proposed as treatment regimens, there are no data on the effectiveness and safety of post-exposure prophylaxis (PEP) for COVID-19. After a large COVID-19 exposure event in a LTCH in Korea, PEP using hydroxychloroquine (HCQ) was conducted to 211 persons including 189 patients and 22 careworkers, whose baseline polymerase chain reaction (PCR) tests for COVID-19 were negative. PEP was completed in 184 (97.4%) patients and 21 (95.5%) careworkers without serious adverse events. At the end of 14 days of quarantine, follow-up PCR tests were all negative. Based on our experience, further clinical studies would be conducted for COVID-19 PEP.
Copyright ? 2020 Elsevier Ltd. All rights reserved.
KEYWORDS:
COVID-19; Hydroxychloroquine; Long-term care hospital; Post-exposure prophylaxis; SARS-CoV-2
PMID:32305587PMCID:PMC7162746DOI:10.1016/j.ijantimicag.2020.105988
Can post-exposure prophylaxis for COVID-19 be considered as one of outbreak response strategies in long-term care hospitals?
Lee SH[SUP]1[/SUP], Son H[SUP]2[/SUP], Peck KR[SUP]3[/SUP].
Author information
Abstract
With ongoing global outbreak of coronavirus disease 2019 (COVID-19), management of exposure events is a concern. Long-term care hospitals (LTCHs) are especially vulnerable to cluster outbreaks, since it is difficult to find facilities and healthcare personnel for their separate isolation care in a large outbreak situation. Although several drugs have been proposed as treatment regimens, there are no data on the effectiveness and safety of post-exposure prophylaxis (PEP) for COVID-19. After a large COVID-19 exposure event in a LTCH in Korea, PEP using hydroxychloroquine (HCQ) was conducted to 211 persons including 189 patients and 22 careworkers, whose baseline polymerase chain reaction (PCR) tests for COVID-19 were negative. PEP was completed in 184 (97.4%) patients and 21 (95.5%) careworkers without serious adverse events. At the end of 14 days of quarantine, follow-up PCR tests were all negative. Based on our experience, further clinical studies would be conducted for COVID-19 PEP.
Copyright ? 2020 Elsevier Ltd. All rights reserved.
KEYWORDS:
COVID-19; Hydroxychloroquine; Long-term care hospital; Post-exposure prophylaxis; SARS-CoV-2
PMID:32305587PMCID:PMC7162746DOI:10.1016/j.ijantimicag.2020.105988