tetano
Editor, Senior Moderator
Int Immunopharmacol
. 2022 Nov 7;113(Pt B):109428.
doi: 10.1016/j.intimp.2022.109428. Online ahead of print.
Role of SARS-CoV-2-induced cytokine storm in multi-organ failure: Molecular pathways and potential therapeutic options
Yasaman Nazerian[SUP] 1 [/SUP], Mobina Ghasemi[SUP] 1 [/SUP], Younes Yassaghi[SUP] 1 [/SUP], Amirhossein Nazerian[SUP] 2 [/SUP], Seyed Mahmoud Hashemi[SUP] 3 [/SUP]
Affiliations
Abstract
Coronavirus disease 2019 (COVID-19) outbreak has become a global public health emergency and has led to devastating results. Mounting evidence proposes that the disease causes severe pulmonary involvement and influences different organs, leading to a critical situation named multi-organ failure. It is yet to be fully clarified how the disease becomes so deadly in some patients. However, it is proven that a condition called "cytokine storm" is involved in the deterioration of COVID-19. Although beneficial, sustained production of cytokines and overabundance of inflammatory mediators causing cytokine storm can lead to collateral vital organ damages. Furthermore, cytokine storm can cause post-COVID-19 syndrome (PCS), an important cause of morbidity after the acute phase of COVID-19. Herein, we aim to explain the possible pathophysiology mechanisms involved in COVID-19-related cytokine storm and its association with multi-organ failure and PCS. We also discuss the latest advances in finding the potential therapeutic targets to control cytokine storm wishing to answer unmet clinical demands for treatment of COVID-19.
Keywords: COVID-19; Cytokine storm; Multiple organ failure; Oxidative stress; Post-COVID-19 syndrome; SARS-CoV-2.
. 2022 Nov 7;113(Pt B):109428.
doi: 10.1016/j.intimp.2022.109428. Online ahead of print.
Role of SARS-CoV-2-induced cytokine storm in multi-organ failure: Molecular pathways and potential therapeutic options
Yasaman Nazerian[SUP] 1 [/SUP], Mobina Ghasemi[SUP] 1 [/SUP], Younes Yassaghi[SUP] 1 [/SUP], Amirhossein Nazerian[SUP] 2 [/SUP], Seyed Mahmoud Hashemi[SUP] 3 [/SUP]
Affiliations
- PMID: 36379152
- PMCID: PMC9637536
- DOI: 10.1016/j.intimp.2022.109428
Abstract
Coronavirus disease 2019 (COVID-19) outbreak has become a global public health emergency and has led to devastating results. Mounting evidence proposes that the disease causes severe pulmonary involvement and influences different organs, leading to a critical situation named multi-organ failure. It is yet to be fully clarified how the disease becomes so deadly in some patients. However, it is proven that a condition called "cytokine storm" is involved in the deterioration of COVID-19. Although beneficial, sustained production of cytokines and overabundance of inflammatory mediators causing cytokine storm can lead to collateral vital organ damages. Furthermore, cytokine storm can cause post-COVID-19 syndrome (PCS), an important cause of morbidity after the acute phase of COVID-19. Herein, we aim to explain the possible pathophysiology mechanisms involved in COVID-19-related cytokine storm and its association with multi-organ failure and PCS. We also discuss the latest advances in finding the potential therapeutic targets to control cytokine storm wishing to answer unmet clinical demands for treatment of COVID-19.
Keywords: COVID-19; Cytokine storm; Multiple organ failure; Oxidative stress; Post-COVID-19 syndrome; SARS-CoV-2.