tetano
Editor, Senior Moderator
Int Immunopharmacol
. 2021 Oct 4;101(Pt B):108217.
doi: 10.1016/j.intimp.2021.108217. Online ahead of print.
Immunotherapy of multisystem inflammatory syndrome in children (MIS-C) following COVID-19 through mesenchymal stem cells
Wanich Suksatan[SUP] 1 [/SUP], Supat Chupradit[SUP] 2 [/SUP], Alexei Valerievich Yumashev[SUP] 3 [/SUP], Sahithya Ravali[SUP] 4 [/SUP], Mohammed Nader Shalaby[SUP] 5 [/SUP], Yasser Fakri Mustafa[SUP] 6 [/SUP], Anatoley Kurochkin[SUP] 7 [/SUP], Homayoon Siahmansouri[SUP] 8 [/SUP]
Affiliations
Abstract
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a new type of coronavirus causing coronavirus 2019 (COVID-19) that was first observed in Wuhan, China, in Dec. 2019. An inflammatory immune response targeting children appeared during the pandemic, which was associated with COVID-19 named multisystem inflammatory syndrome in children (MIS-C). Characteristics of MIS-C include the classic inflammation findings, multi-organ dysfunction, and fever as the cardinal feature. Up to now, no specific therapy has been identified for MIS-C. Currently, considerable progress has been obtained in the MIS-C treatment by cell therapy, specially Mesenchymal stem cells (MSCs). Unique properties have been reported for MSCs, such as various resources for purification of cell, high proliferation, self-renewal, non-invasive procedure, tissue regenerator, multidirectional differentiation, and immunosuppression. As indicated by a recent clinical research, MSCs have the ability of reducing disease inflammation and severity in children with MIS-C. In the present review study, the benefits and characteristics of MSCs and exosomes are discussed for treating patients with MIS-C.
Keywords: Coronavirus disease 2019; Exosomes; MIS-C; Mesenchymal stem cell.
. 2021 Oct 4;101(Pt B):108217.
doi: 10.1016/j.intimp.2021.108217. Online ahead of print.
Immunotherapy of multisystem inflammatory syndrome in children (MIS-C) following COVID-19 through mesenchymal stem cells
Wanich Suksatan[SUP] 1 [/SUP], Supat Chupradit[SUP] 2 [/SUP], Alexei Valerievich Yumashev[SUP] 3 [/SUP], Sahithya Ravali[SUP] 4 [/SUP], Mohammed Nader Shalaby[SUP] 5 [/SUP], Yasser Fakri Mustafa[SUP] 6 [/SUP], Anatoley Kurochkin[SUP] 7 [/SUP], Homayoon Siahmansouri[SUP] 8 [/SUP]
Affiliations
- PMID: 34627083
- PMCID: PMC8487784
- DOI: 10.1016/j.intimp.2021.108217
Abstract
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a new type of coronavirus causing coronavirus 2019 (COVID-19) that was first observed in Wuhan, China, in Dec. 2019. An inflammatory immune response targeting children appeared during the pandemic, which was associated with COVID-19 named multisystem inflammatory syndrome in children (MIS-C). Characteristics of MIS-C include the classic inflammation findings, multi-organ dysfunction, and fever as the cardinal feature. Up to now, no specific therapy has been identified for MIS-C. Currently, considerable progress has been obtained in the MIS-C treatment by cell therapy, specially Mesenchymal stem cells (MSCs). Unique properties have been reported for MSCs, such as various resources for purification of cell, high proliferation, self-renewal, non-invasive procedure, tissue regenerator, multidirectional differentiation, and immunosuppression. As indicated by a recent clinical research, MSCs have the ability of reducing disease inflammation and severity in children with MIS-C. In the present review study, the benefits and characteristics of MSCs and exosomes are discussed for treating patients with MIS-C.
Keywords: Coronavirus disease 2019; Exosomes; MIS-C; Mesenchymal stem cell.