tetano
Editor, Senior Moderator
Int Immunopharmacol
. 2021 Oct 6;101(Pt B):108226.
doi: 10.1016/j.intimp.2021.108226. Online ahead of print.
An overview of the recent findings of cell-based therapies for the treatment and management of COVID-19
Sasan Ghaffari[SUP] 1 [/SUP], Hanif Kazerooni[SUP] 2 [/SUP], Amir Salehi-Najafabadi[SUP] 3 [/SUP]
Affiliations
Abstract
The coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a global pandemic taking the lives of millions. The virus itself not only invades and destroys the angiotensin-converting enzyme 2 (ACE2)-expressing cells of the lungs, kidneys, liver, etc. but also elicits a hyperinflammatory immune response, further damaging the tissue leading to acute respiratory distress syndrome (ARDS) and death. Although vaccines, as a prime example of active immunotherapy, have clearly disrupted the transmission of virus and reduced mortality, hospitalization, and burden of disease, other avenues of immunotherapy are also being explored. One such approach would be to adoptively transfer modified/unmodified immune cells to the critically ill. Here, we compiled and summarized the immunopathogenesis of SARS-CoV-2 and the recent preclinical and clinical data on the potential of cell-based therapies in the fight against COVID-19.
Keywords: Adoptive immunotherapy; COVID-19; SARS-CoV-2; T cell; Vaccine.
. 2021 Oct 6;101(Pt B):108226.
doi: 10.1016/j.intimp.2021.108226. Online ahead of print.
An overview of the recent findings of cell-based therapies for the treatment and management of COVID-19
Sasan Ghaffari[SUP] 1 [/SUP], Hanif Kazerooni[SUP] 2 [/SUP], Amir Salehi-Najafabadi[SUP] 3 [/SUP]
Affiliations
- PMID: 34634685
- DOI: 10.1016/j.intimp.2021.108226
Abstract
The coronavirus disease 2019 (COVID-19) caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has become a global pandemic taking the lives of millions. The virus itself not only invades and destroys the angiotensin-converting enzyme 2 (ACE2)-expressing cells of the lungs, kidneys, liver, etc. but also elicits a hyperinflammatory immune response, further damaging the tissue leading to acute respiratory distress syndrome (ARDS) and death. Although vaccines, as a prime example of active immunotherapy, have clearly disrupted the transmission of virus and reduced mortality, hospitalization, and burden of disease, other avenues of immunotherapy are also being explored. One such approach would be to adoptively transfer modified/unmodified immune cells to the critically ill. Here, we compiled and summarized the immunopathogenesis of SARS-CoV-2 and the recent preclinical and clinical data on the potential of cell-based therapies in the fight against COVID-19.
Keywords: Adoptive immunotherapy; COVID-19; SARS-CoV-2; T cell; Vaccine.