Mary Wilson
Well-known member
Available online 9 November 2021.
https://doi.org/10.1016/j.coi.2021.10.007
Eleanor CSemmes[SUP]1[/SUP][SUP]2[/SUP][SUP]3 [/SUP]Carolyn BCoyne[SUP]2[/SUP][SUP]3[/SUP]
Highlights
•Decidual natural killer (dNK) cells transfer anti-microbial peptides to placental trophoblasts to defend against infections.
•Newly described maternal placenta-associated macrophages and monocytes (PAMMs) may function in innate immune defense.
•Fetal-derived placental macrophages mount innate immune responses, yet may also be viral reservoirs for TORCH pathogens.
•Anti-viral interferon secretion by placental trophoblasts contributes to placental dysfunction in congenital infections.
•Novel organoid models and single-cell technologies can be applied to innate immunity at the human maternal-fetal interface
https://www.sciencedirect.com/science/article/pii/S0952791521001400?dgcid=coauthor
https://doi.org/10.1016/j.coi.2021.10.007
Eleanor CSemmes[SUP]1[/SUP][SUP]2[/SUP][SUP]3 [/SUP]Carolyn BCoyne[SUP]2[/SUP][SUP]3[/SUP]
Highlights
•Decidual natural killer (dNK) cells transfer anti-microbial peptides to placental trophoblasts to defend against infections.
•Newly described maternal placenta-associated macrophages and monocytes (PAMMs) may function in innate immune defense.
•Fetal-derived placental macrophages mount innate immune responses, yet may also be viral reservoirs for TORCH pathogens.
•Anti-viral interferon secretion by placental trophoblasts contributes to placental dysfunction in congenital infections.
•Novel organoid models and single-cell technologies can be applied to innate immunity at the human maternal-fetal interface
https://www.sciencedirect.com/science/article/pii/S0952791521001400?dgcid=coauthor