tetano
Editor, Senior Moderator
Int J Infect Dis. 2019 Aug 27. pii: S1201-9712(19)30348-0. doi: 10.1016/j.ijid.2019.08.022. [Epub ahead of print]
[h=1]Influenza virus seroincidence in a cohort of healthy and high-risk children enrolled in infancy, Bangkok, Thailand.[/h] Rungrojcharoenkit K[SUP]1[/SUP], Kittikraisak W[SUP]2[/SUP], Ditsungnoen D[SUP]3[/SUP], Olsen SJ[SUP]4[/SUP], Suntarattiwong P[SUP]5[/SUP], Chotpitayasunondh T[SUP]5[/SUP], Klungthong C[SUP]1[/SUP], Yoon IK[SUP]1[/SUP], Dawood FS[SUP]4[/SUP], Fernandez S[SUP]1[/SUP], Macareo L[SUP]1[/SUP], Lindblade KA[SUP]6[/SUP].
[h=3]Author information[/h] 1 Virolgy Department, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand. 2 Influenza Program, Thailand Ministry of Public Health - U.S. Centers for Diseases Control and Prevention Collaboration, Nonthaburi, Thailand. Electronic address: glr9@cdc.gov. 3 Influenza Program, Thailand Ministry of Public Health - U.S. Centers for Diseases Control and Prevention Collaboration, Nonthaburi, Thailand. 4 Influenza Division, U.S. Centers Disease Control and Prevention, Atlanta, Georgia. 5 Queen Sirikit National Institute of Child Health, Bangkok, Thailand. 6 Influenza Program, Thailand Ministry of Public Health - U.S. Centers for Diseases Control and Prevention Collaboration, Nonthaburi, Thailand; Influenza Division, U.S. Centers Disease Control and Prevention, Atlanta, Georgia.
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] We measured seroconversion to influenza viruses and incidence of symptomatic influenza virus infection in a cohort of children in Bangkok, Thailand.
[h=4]METHODS:[/h] Children aged ≤6 months were followed for two years for acute respiratory illness and had serum specimens taken at 6-month intervals and tested by hemagglutination inhibition (HI) assay. Seroconversion was defined as a >4-fold rise in the HI titers between time points with a titer of >40 in the second specimen. Respiratory swabs were tested by rRT-PCR for influenza. Data were analyzed using generalized linear models.
[h=4]RESULTS:[/h] Of 350 children, 266 (76%, 147 were healthy and 119 high-risk) had ≥2 serum specimens collected before influenza vaccination. During the 2-year follow-up, 266 children contributed 370 person-years of observation, excluding post-vaccination periods. We identified 32 ARI cases with rRT-PCR-confirmed influenza virus infection (7 infections/100 person-years, 95% confidence interval [CI], 4-11). There were 126 episodes of influenza virus infection, resulting in a seroconversion rate of 35 infections/100 person-years (95% CI, 30-42). Rates in healthy and high-risk children did not differ.
[h=4]CONCLUSIONS:[/h] Influenza virus infection is common during the first two years of life among Thai children. A large proportion of infections may not be detected using the ARI case definition.
Copyright ? 2019. Published by Elsevier Ltd.
[h=4]KEYWORDS:[/h] Influenza; Pediatric; Seroconversion; Seroincidence; Thailand
PMID: 31470089 DOI: 10.1016/j.ijid.2019.08.022
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[h=1]Influenza virus seroincidence in a cohort of healthy and high-risk children enrolled in infancy, Bangkok, Thailand.[/h] Rungrojcharoenkit K[SUP]1[/SUP], Kittikraisak W[SUP]2[/SUP], Ditsungnoen D[SUP]3[/SUP], Olsen SJ[SUP]4[/SUP], Suntarattiwong P[SUP]5[/SUP], Chotpitayasunondh T[SUP]5[/SUP], Klungthong C[SUP]1[/SUP], Yoon IK[SUP]1[/SUP], Dawood FS[SUP]4[/SUP], Fernandez S[SUP]1[/SUP], Macareo L[SUP]1[/SUP], Lindblade KA[SUP]6[/SUP].
[h=3]Author information[/h] 1 Virolgy Department, Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand. 2 Influenza Program, Thailand Ministry of Public Health - U.S. Centers for Diseases Control and Prevention Collaboration, Nonthaburi, Thailand. Electronic address: glr9@cdc.gov. 3 Influenza Program, Thailand Ministry of Public Health - U.S. Centers for Diseases Control and Prevention Collaboration, Nonthaburi, Thailand. 4 Influenza Division, U.S. Centers Disease Control and Prevention, Atlanta, Georgia. 5 Queen Sirikit National Institute of Child Health, Bangkok, Thailand. 6 Influenza Program, Thailand Ministry of Public Health - U.S. Centers for Diseases Control and Prevention Collaboration, Nonthaburi, Thailand; Influenza Division, U.S. Centers Disease Control and Prevention, Atlanta, Georgia.
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] We measured seroconversion to influenza viruses and incidence of symptomatic influenza virus infection in a cohort of children in Bangkok, Thailand.
[h=4]METHODS:[/h] Children aged ≤6 months were followed for two years for acute respiratory illness and had serum specimens taken at 6-month intervals and tested by hemagglutination inhibition (HI) assay. Seroconversion was defined as a >4-fold rise in the HI titers between time points with a titer of >40 in the second specimen. Respiratory swabs were tested by rRT-PCR for influenza. Data were analyzed using generalized linear models.
[h=4]RESULTS:[/h] Of 350 children, 266 (76%, 147 were healthy and 119 high-risk) had ≥2 serum specimens collected before influenza vaccination. During the 2-year follow-up, 266 children contributed 370 person-years of observation, excluding post-vaccination periods. We identified 32 ARI cases with rRT-PCR-confirmed influenza virus infection (7 infections/100 person-years, 95% confidence interval [CI], 4-11). There were 126 episodes of influenza virus infection, resulting in a seroconversion rate of 35 infections/100 person-years (95% CI, 30-42). Rates in healthy and high-risk children did not differ.
[h=4]CONCLUSIONS:[/h] Influenza virus infection is common during the first two years of life among Thai children. A large proportion of infections may not be detected using the ARI case definition.
Copyright ? 2019. Published by Elsevier Ltd.
[h=4]KEYWORDS:[/h] Influenza; Pediatric; Seroconversion; Seroincidence; Thailand
PMID: 31470089 DOI: 10.1016/j.ijid.2019.08.022
Free full text