tetano
Editor, Senior Moderator
Biochim Biophys Acta. 2016 Sep 21. pii: S1874-9399(16)30190-0. doi: 10.1016/j.bbagrm.2016.09.005. [Epub ahead of print]
[h=1]Influenza virus NS1 protein binds cellular DNA to block transcription of antiviral genes.[/h] Anastasina M[SUP]1[/SUP], Le May N[SUP]2[/SUP], Bugai A[SUP]3[/SUP], Fu Y[SUP]4[/SUP], S?derholm S[SUP]5[/SUP], Gaelings L[SUP]4[/SUP], Ohman T[SUP]5[/SUP], Tynell J[SUP]6[/SUP], Kytt?nen S[SUP]4[/SUP], Barboric M[SUP]3[/SUP], Nyman TA[SUP]7[/SUP], Matikainen S[SUP]3[/SUP], Julkunen I[SUP]8[/SUP], Butcher SJ[SUP]5[/SUP], Egly JM[SUP]9[/SUP], Kainov DE[SUP]10[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Influenza NS1 protein is an important virulence factor that is capable of binding double-stranded (ds) RNA and inhibiting dsRNA-mediated host innate immune responses. Here we show that NS1 can also bind cellular dsDNA. This interaction prevents loading of transcriptional machinery to the DNA, thereby attenuating IAV-mediated expression of antiviral genes. Thus, we identified a previously undescribed strategy, by which RNA virus inhibits cellular transcription to escape antiviral response and secure its replication.
Copyright ? 2016. Published by Elsevier B.V.
[h=4]KEYWORDS:[/h] Antiviral responses; Influenza A virus; Innate immunity; Regulation of gene expression; Viral counter-responses
PMID: 27664935 DOI: 10.1016/j.bbagrm.2016.09.005
[PubMed - as supplied by publisher]
[h=1]Influenza virus NS1 protein binds cellular DNA to block transcription of antiviral genes.[/h] Anastasina M[SUP]1[/SUP], Le May N[SUP]2[/SUP], Bugai A[SUP]3[/SUP], Fu Y[SUP]4[/SUP], S?derholm S[SUP]5[/SUP], Gaelings L[SUP]4[/SUP], Ohman T[SUP]5[/SUP], Tynell J[SUP]6[/SUP], Kytt?nen S[SUP]4[/SUP], Barboric M[SUP]3[/SUP], Nyman TA[SUP]7[/SUP], Matikainen S[SUP]3[/SUP], Julkunen I[SUP]8[/SUP], Butcher SJ[SUP]5[/SUP], Egly JM[SUP]9[/SUP], Kainov DE[SUP]10[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Influenza NS1 protein is an important virulence factor that is capable of binding double-stranded (ds) RNA and inhibiting dsRNA-mediated host innate immune responses. Here we show that NS1 can also bind cellular dsDNA. This interaction prevents loading of transcriptional machinery to the DNA, thereby attenuating IAV-mediated expression of antiviral genes. Thus, we identified a previously undescribed strategy, by which RNA virus inhibits cellular transcription to escape antiviral response and secure its replication.
Copyright ? 2016. Published by Elsevier B.V.
[h=4]KEYWORDS:[/h] Antiviral responses; Influenza A virus; Innate immunity; Regulation of gene expression; Viral counter-responses
PMID: 27664935 DOI: 10.1016/j.bbagrm.2016.09.005
[PubMed - as supplied by publisher]