tetano
Editor, Senior Moderator
Arch Virol. 2016 Nov 16. [Epub ahead of print]
[h=1]Influenza virus infection induces translocation of apoptosis-inducing factor (AIF) in A549 cells: role of AIF in apoptosis and viral propagation.[/h] Qu X[SUP]1,[/SUP][SUP]2[/SUP], Ding X[SUP]1[/SUP], Duan M[SUP]1,[/SUP][SUP]3[/SUP], Yang J[SUP]1[/SUP], Lin R[SUP]1[/SUP], Zhou Z[SUP]4[/SUP], Wang S[SUP]5[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] It is recognized that influenza virus induces caspase-dependent apoptosis by activating caspase-3. Apoptosis-inducing factor (AIF) is a caspase-independent cell death effector, and its mitochondrial-nuclear translocation plays an important role in apoptosis. It is demonstrated in this study how influenza virus infection can induce caspase-independent apoptosis in the human alveolar epithelial cell line A549. AIF is translocated from the mitochondria to the nucleus in a caspase-independent manner in response to infection with influenza virus. Knockdown of AIF expression by small interfering RNA (siRNA) led to a reduction in virus-infection-induced apoptosis and virus yield. These results indicate that AIF translocation has a role in influenza-virus-induced apoptosis.
PMID: 27853862 DOI: 10.1007/s00705-016-3151-x
[PubMed - as supplied by publisher]
[h=1]Influenza virus infection induces translocation of apoptosis-inducing factor (AIF) in A549 cells: role of AIF in apoptosis and viral propagation.[/h] Qu X[SUP]1,[/SUP][SUP]2[/SUP], Ding X[SUP]1[/SUP], Duan M[SUP]1,[/SUP][SUP]3[/SUP], Yang J[SUP]1[/SUP], Lin R[SUP]1[/SUP], Zhou Z[SUP]4[/SUP], Wang S[SUP]5[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] It is recognized that influenza virus induces caspase-dependent apoptosis by activating caspase-3. Apoptosis-inducing factor (AIF) is a caspase-independent cell death effector, and its mitochondrial-nuclear translocation plays an important role in apoptosis. It is demonstrated in this study how influenza virus infection can induce caspase-independent apoptosis in the human alveolar epithelial cell line A549. AIF is translocated from the mitochondria to the nucleus in a caspase-independent manner in response to infection with influenza virus. Knockdown of AIF expression by small interfering RNA (siRNA) led to a reduction in virus-infection-induced apoptosis and virus yield. These results indicate that AIF translocation has a role in influenza-virus-induced apoptosis.
PMID: 27853862 DOI: 10.1007/s00705-016-3151-x
[PubMed - as supplied by publisher]