tetano
Editor, Senior Moderator
Clin Infect Dis. 2013 Feb 14. [Epub ahead of print]
Influenza Vaccine Effectiveness in the Community and the Household.
Ohmit SE, Petrie JG, Malosh RE, Cowling BJ, Thompson MG, Shay DK, Monto AS.
Source
Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor Michigan, USA.
Abstract
Background. There is a recognized need to determine influenza vaccine effectiveness on an annual basis and a long history of studying respiratory illnesses in households.Methods. We recruited 328 households with 1,441 members, including 839 children, and followed them during the 2010-2011 influenza season. Specimens were collected from subjects with reported acute respiratory illnesses and tested by RT-PCR. Receipt of influenza vaccine was defined based on documented evidence of vaccination in medical records or an immunization registry. The effectiveness of 2010-2011 influenza vaccination in preventing laboratory-confirmed influenza was estimated using Cox proportional hazards models adjusted for age and presence of high-risk condition, and stratified by prior season (2009-2010) vaccination status.Results. Influenza was identified in 78 (24%) households and 125 (9%) individuals; the infection risk was 8.5% in the vaccinated and 8.9% in the unvaccinated (P=.83). Adjusted vaccine effectiveness in preventing community-acquired influenza was 31% (95% CI: -7 to 55%). In vaccinated subjects with no evidence of prior season vaccination, significant protection (62%, 95% CI: 17 to 82%) against community-acquired influenza was demonstrated. Substantially lower effectiveness was noted among subjects who were vaccinated in both the current and prior season. There was no evidence that vaccination prevented household transmission once influenza was introduced; adults were at particular risk despite vaccination.Conclusions. Vaccine effectiveness estimates were lower than those demonstrated in other observational studies carried out during the same season. The unexpected findings of lower effectiveness with repeated vaccination and no protection given household exposure require further study.
PMID:
23413420
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/23413420
Influenza Vaccine Effectiveness in the Community and the Household.
Ohmit SE, Petrie JG, Malosh RE, Cowling BJ, Thompson MG, Shay DK, Monto AS.
Source
Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor Michigan, USA.
Abstract
Background. There is a recognized need to determine influenza vaccine effectiveness on an annual basis and a long history of studying respiratory illnesses in households.Methods. We recruited 328 households with 1,441 members, including 839 children, and followed them during the 2010-2011 influenza season. Specimens were collected from subjects with reported acute respiratory illnesses and tested by RT-PCR. Receipt of influenza vaccine was defined based on documented evidence of vaccination in medical records or an immunization registry. The effectiveness of 2010-2011 influenza vaccination in preventing laboratory-confirmed influenza was estimated using Cox proportional hazards models adjusted for age and presence of high-risk condition, and stratified by prior season (2009-2010) vaccination status.Results. Influenza was identified in 78 (24%) households and 125 (9%) individuals; the infection risk was 8.5% in the vaccinated and 8.9% in the unvaccinated (P=.83). Adjusted vaccine effectiveness in preventing community-acquired influenza was 31% (95% CI: -7 to 55%). In vaccinated subjects with no evidence of prior season vaccination, significant protection (62%, 95% CI: 17 to 82%) against community-acquired influenza was demonstrated. Substantially lower effectiveness was noted among subjects who were vaccinated in both the current and prior season. There was no evidence that vaccination prevented household transmission once influenza was introduced; adults were at particular risk despite vaccination.Conclusions. Vaccine effectiveness estimates were lower than those demonstrated in other observational studies carried out during the same season. The unexpected findings of lower effectiveness with repeated vaccination and no protection given household exposure require further study.
PMID:
23413420
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/23413420