tetano
Editor, Senior Moderator
J Infect Dis. 2019 Sep 24. pii: jiz419. doi: 10.1093/infdis/jiz419. [Epub ahead of print]
[h=1]Influenza Vaccine Effectiveness in Preventing Hospitalizations in Older Patients With Chronic Obstructive Pulmonary Disease.[/h] Gershon AS[SUP]1,[/SUP][SUP]2,[/SUP][SUP]3,[/SUP][SUP]4,[/SUP][SUP]5[/SUP], Chung H[SUP]2[/SUP], Porter J[SUP]2[/SUP], Campitelli MA[SUP]2[/SUP], Buchan SA[SUP]2,[/SUP][SUP]4,[/SUP][SUP]6[/SUP], Schwartz KL[SUP]2,[/SUP][SUP]4,[/SUP][SUP]6[/SUP], Crowcroft NS[SUP]4,[/SUP][SUP]7,[/SUP][SUP]6[/SUP], Campigotto A[SUP]5,[/SUP][SUP]8[/SUP], Gubbay JB[SUP]7,[/SUP][SUP]6,[/SUP][SUP]5[/SUP], Karnauchow T[SUP]9,[/SUP][SUP]10[/SUP], Katz K[SUP]11[/SUP], McGeer AJ[SUP]4,[/SUP][SUP]7,[/SUP][SUP]12[/SUP], McNally JD[SUP]9[/SUP], Richardson DC[SUP]13[/SUP], Richardson SE[SUP]7,[/SUP][SUP]5[/SUP], Rosella LC[SUP]2,[/SUP][SUP]4,[/SUP][SUP]6[/SUP], Simor AE[SUP]1,[/SUP][SUP]7[/SUP], Smieja M[SUP]14[/SUP], Zahariadis G[SUP]5,[/SUP][SUP]15[/SUP], Kwong JC[SUP]2,[/SUP][SUP]4,[/SUP][SUP]16,[/SUP][SUP]6,[/SUP][SUP]17[/SUP].
[h=3]Author information[/h] 1 Department of Medicine, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada. 2 ICES, Toronto, Ontario, Canada. 3 Department of Medicine, University of Toronto, Ontario, Canada. 4 Dalla Lana School of Public Health, University of Toronto, Ontario, Canada. 5 Hospital for Sick Children, Toronto, Ontario, Canada. 6 Public Health Ontario, Toronto, Canada. 7 Department of Laboratory Medicine and Pathobiology, University of Toronto, Ontario, Canada. 8 London Health Sciences Centre, Ontario, Canada. 9 Children's Hospital of Eastern Ontario, Ottawa, Canada. 10 Department of Pathology and Laboratory Medicine, University of Ottawa, Ontario, Canada. 11 North York General Hospital, Toronto, Ontario, Canada. 12 Department of Microbiology Sinai Health System, Toronto, Ontario, Canada. 13 William Osler Health System, Brampton, Ontario, Canada. 14 McMaster University, Hamilton, Ontario, Canada. 15 Newfoundland and Labrador Public Health Laboratory, St. John's, Canada. 16 Department of Family and Community Medicine, University of Toronto, Ontario, Canada. 17 University Health Network, Toronto, Ontario, Canada.
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] Annual influenza immunization is recommended for people with chronic obstructive pulmonary disease (COPD) by all major COPD clinical practice guidelines. We sought to determine the seasonal influenza vaccine effectiveness (VE) against laboratory-confirmed influenza-associated hospitalizations among older adults with COPD.
[h=4]METHODS:[/h] We conducted a test-negative study of influenza VE in community-dwelling older adults with COPD in Ontario, Canada using health administrative data and respiratory specimens collected from patients tested for influenza during the 2010-11 to 2015-16 influenza seasons. Influenza vaccination was ascertained from physician and pharmacist billing claims. Multivariable logistic regression was used to estimate the adjusted odds ratio of influenza vaccination in people with, compared to those without, laboratory-confirmed influenza.
[h=4]RESULTS:[/h] Receipt of seasonal influenza vaccine was associated with an adjusted 22% (95% confidence interval [CI], 15%-27%) reduction in laboratory-confirmed influenza-associated hospitalization. Adjustment for potential misclassification of vaccination status increased this to 43% (95% CI, 35%-52%). Vaccine effectiveness was not found to vary by patient- or influenza-related variables.
[h=4]CONCLUSIONS:[/h] During the studied influenza seasons, influenza vaccination was at least modestly effective in reducing laboratory-confirmed influenza-associated hospitalizations in people with COPD. The imperfect effectiveness emphasizes the need for better influenza vaccines and other preventive strategies.
? The Author(s) 2019. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.
[h=4]KEYWORDS:[/h] chronic obstructive pulmonary disease (COPD); influenza vaccine; vaccine effectiveness
PMID: 31549165 DOI: 10.1093/infdis/jiz419
[h=1]Influenza Vaccine Effectiveness in Preventing Hospitalizations in Older Patients With Chronic Obstructive Pulmonary Disease.[/h] Gershon AS[SUP]1,[/SUP][SUP]2,[/SUP][SUP]3,[/SUP][SUP]4,[/SUP][SUP]5[/SUP], Chung H[SUP]2[/SUP], Porter J[SUP]2[/SUP], Campitelli MA[SUP]2[/SUP], Buchan SA[SUP]2,[/SUP][SUP]4,[/SUP][SUP]6[/SUP], Schwartz KL[SUP]2,[/SUP][SUP]4,[/SUP][SUP]6[/SUP], Crowcroft NS[SUP]4,[/SUP][SUP]7,[/SUP][SUP]6[/SUP], Campigotto A[SUP]5,[/SUP][SUP]8[/SUP], Gubbay JB[SUP]7,[/SUP][SUP]6,[/SUP][SUP]5[/SUP], Karnauchow T[SUP]9,[/SUP][SUP]10[/SUP], Katz K[SUP]11[/SUP], McGeer AJ[SUP]4,[/SUP][SUP]7,[/SUP][SUP]12[/SUP], McNally JD[SUP]9[/SUP], Richardson DC[SUP]13[/SUP], Richardson SE[SUP]7,[/SUP][SUP]5[/SUP], Rosella LC[SUP]2,[/SUP][SUP]4,[/SUP][SUP]6[/SUP], Simor AE[SUP]1,[/SUP][SUP]7[/SUP], Smieja M[SUP]14[/SUP], Zahariadis G[SUP]5,[/SUP][SUP]15[/SUP], Kwong JC[SUP]2,[/SUP][SUP]4,[/SUP][SUP]16,[/SUP][SUP]6,[/SUP][SUP]17[/SUP].
[h=3]Author information[/h] 1 Department of Medicine, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada. 2 ICES, Toronto, Ontario, Canada. 3 Department of Medicine, University of Toronto, Ontario, Canada. 4 Dalla Lana School of Public Health, University of Toronto, Ontario, Canada. 5 Hospital for Sick Children, Toronto, Ontario, Canada. 6 Public Health Ontario, Toronto, Canada. 7 Department of Laboratory Medicine and Pathobiology, University of Toronto, Ontario, Canada. 8 London Health Sciences Centre, Ontario, Canada. 9 Children's Hospital of Eastern Ontario, Ottawa, Canada. 10 Department of Pathology and Laboratory Medicine, University of Ottawa, Ontario, Canada. 11 North York General Hospital, Toronto, Ontario, Canada. 12 Department of Microbiology Sinai Health System, Toronto, Ontario, Canada. 13 William Osler Health System, Brampton, Ontario, Canada. 14 McMaster University, Hamilton, Ontario, Canada. 15 Newfoundland and Labrador Public Health Laboratory, St. John's, Canada. 16 Department of Family and Community Medicine, University of Toronto, Ontario, Canada. 17 University Health Network, Toronto, Ontario, Canada.
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] Annual influenza immunization is recommended for people with chronic obstructive pulmonary disease (COPD) by all major COPD clinical practice guidelines. We sought to determine the seasonal influenza vaccine effectiveness (VE) against laboratory-confirmed influenza-associated hospitalizations among older adults with COPD.
[h=4]METHODS:[/h] We conducted a test-negative study of influenza VE in community-dwelling older adults with COPD in Ontario, Canada using health administrative data and respiratory specimens collected from patients tested for influenza during the 2010-11 to 2015-16 influenza seasons. Influenza vaccination was ascertained from physician and pharmacist billing claims. Multivariable logistic regression was used to estimate the adjusted odds ratio of influenza vaccination in people with, compared to those without, laboratory-confirmed influenza.
[h=4]RESULTS:[/h] Receipt of seasonal influenza vaccine was associated with an adjusted 22% (95% confidence interval [CI], 15%-27%) reduction in laboratory-confirmed influenza-associated hospitalization. Adjustment for potential misclassification of vaccination status increased this to 43% (95% CI, 35%-52%). Vaccine effectiveness was not found to vary by patient- or influenza-related variables.
[h=4]CONCLUSIONS:[/h] During the studied influenza seasons, influenza vaccination was at least modestly effective in reducing laboratory-confirmed influenza-associated hospitalizations in people with COPD. The imperfect effectiveness emphasizes the need for better influenza vaccines and other preventive strategies.
? The Author(s) 2019. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail: journals.permissions@oup.com.
[h=4]KEYWORDS:[/h] chronic obstructive pulmonary disease (COPD); influenza vaccine; vaccine effectiveness
PMID: 31549165 DOI: 10.1093/infdis/jiz419