Influenza vaccine effectiveness in adults 65 years and older, Denmark, 2015/16 - a rapid epidemiological and virological assessment

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Euro Surveill. 2016 Apr 7;21(14). doi: 10.2807/1560-7917.ES.2016.21.14.30189.
[h=1]Influenza vaccine effectiveness in adults 65 years and older, Denmark, 2015/16 - a rapid epidemiological and virological assessment.[/h] Emborg HD[SUP]1[/SUP], Krause TG, Nielsen L, Thomsen MK, Christiansen CB, Skov MN, Nielsen XC, Weinreich LS, Fischer TK, R?nn J, Trebbien R.
[h=3]Author information[/h]

[h=3]Abstract[/h] In Denmark, both influenza A(H1N1)pdm09 and influenza B co-circulated in the 2015/16 season. We estimated the vaccine effectiveness (VE) of the trivalent influenza vaccine in patients 65 years and older using the test-negative case-control design. The adjusted VE against influenza A(H1N1)pdm09 was 35.0% (95% confidence interval (CI): 11.1-52.4) and against influenza B 4.1% (95% CI: -22.0 to 24.7). The majority of influenza A(H1N1)pdm09 circulating in 2015/16 belonged to the new genetic subgroup subclade 6B.1.


[h=4]KEYWORDS:[/h] antigenic characterization; genetic drift; phylogeny; seasonal influenza; vaccine effectiveness

PMID: 27101732 [PubMed - in process]