tetano
Editor, Senior Moderator
Expert Rev Vaccines. 2014 Jun 19:1-10. [Epub ahead of print]
Influenza vaccine effectiveness: best practice and current limitations of the screening method and their implications for the clinic.
Minodier L1, Blanchon T, Souty C, Turbelin C, Leccia F, Varesi L, Falchi A.
Author information
Abstract
Is there a role for the screening method in estimating influenza vaccine effectiveness (VE)? The answer is yes, but the simplicity of the method used has raised concerns about its validity, and several cautions should be noted. The screening method provides an approximation of influenza VE by comparing the proportion of cases vaccinated (PCV) with the proportion of persons vaccinated (PPV) in the general population. This method has an important disadvantage: VE estimation could be inaccurate if the values for PCV and PPV are drawn from different populations, but it has an important strength, compared with other observational studies, in providing an early indication of VE in the field. Thus, when an infrastructure, such as routine surveillance, is in place to collect robust PCV values, and PPV can be obtained from routine vaccine uptake monitoring systems, the screening method can provide early estimates of influenza VE in target groups.
KEYWORDS:
confounding factor; influenza-like illness; outcome measure; screening method; specificity; surveillance; target group; vaccine coverage; vaccine effectiveness; vaccine efficacy
PMID:
24946796
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/24946796
Influenza vaccine effectiveness: best practice and current limitations of the screening method and their implications for the clinic.
Minodier L1, Blanchon T, Souty C, Turbelin C, Leccia F, Varesi L, Falchi A.
Author information
Abstract
Is there a role for the screening method in estimating influenza vaccine effectiveness (VE)? The answer is yes, but the simplicity of the method used has raised concerns about its validity, and several cautions should be noted. The screening method provides an approximation of influenza VE by comparing the proportion of cases vaccinated (PCV) with the proportion of persons vaccinated (PPV) in the general population. This method has an important disadvantage: VE estimation could be inaccurate if the values for PCV and PPV are drawn from different populations, but it has an important strength, compared with other observational studies, in providing an early indication of VE in the field. Thus, when an infrastructure, such as routine surveillance, is in place to collect robust PCV values, and PPV can be obtained from routine vaccine uptake monitoring systems, the screening method can provide early estimates of influenza VE in target groups.
KEYWORDS:
confounding factor; influenza-like illness; outcome measure; screening method; specificity; surveillance; target group; vaccine coverage; vaccine effectiveness; vaccine efficacy
PMID:
24946796
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/24946796