tetano
Editor, Senior Moderator
Pediatr Infect Dis J. 2015 Dec 7. [Epub ahead of print]
[h=1]Influenza Vaccine Effectiveness and Uptake in Children at Risk of Severe Disease.[/h] Blyth CC[SUP]1[/SUP], Jacoby P, Effler PV, Kelly H, Smith DW, Borland ML, Willis GA, Levy A, Keil AD, Richmond PC; WAIVE Study Team.
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] Data demonstrating the effectiveness of inactivated trivalent influenza vaccine (TIV) for children at increased risk of severe disease are limited. Our objective was to determine the effectiveness of TIV in children with risk factors for severe disease and to compare vaccine uptake, parental attitudes and prescriber recommendations in children with and without risk factors for severe disease.
[h=4]METHODS:[/h] Children aged 6-59 months presenting for emergency care (2008-2014) with an influenza-like illness were eligible. Influenza PCR/culture were performed on nasopharyngeal samples. Vaccination status was confirmed via the national register and/or vaccine providers. The test-negative design was used to estimate vaccine effectiveness (VE). Risk factors, parental attitudes and prescriber recommendations were assessed by parental questionnaire.
[h=4]RESULTS:[/h] 2723 children were recruited. Risk factors for severe disease included comorbid medical conditions (11.6%), preterm birth (13.0%) and indigeneity (5.0%). Influenza was identified in 546 (20.1%) participants. Overall VE (2008, 2010-2014) was 70.0% (95%CI: 47.7,82.9); VE for children with medical comorbidities, children born preterm, and children <2 years were 82.5% (14.6,96.4), 79.2% (10.9,95.1) and 84.7% (49.6,95.3) respectively. Following adverse events in 2010, the number of children fully vaccinated with TIV declined significantly. This included children with and without risk factors for severe disease. Attitudes were similar in parents of children with and without risk factors for severe disease.
[h=4]CONCLUSIONS:[/h] VE for TIV in young children with and without risk factors for severe disease was ≥70%. Despite this, participation in the preschool influenza vaccination program remains low with parents and prescribers unconvinced of the benefits and safety of TIV.
PMID: 26646548 [PubMed - as supplied by publisher]
[h=1]Influenza Vaccine Effectiveness and Uptake in Children at Risk of Severe Disease.[/h] Blyth CC[SUP]1[/SUP], Jacoby P, Effler PV, Kelly H, Smith DW, Borland ML, Willis GA, Levy A, Keil AD, Richmond PC; WAIVE Study Team.
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] Data demonstrating the effectiveness of inactivated trivalent influenza vaccine (TIV) for children at increased risk of severe disease are limited. Our objective was to determine the effectiveness of TIV in children with risk factors for severe disease and to compare vaccine uptake, parental attitudes and prescriber recommendations in children with and without risk factors for severe disease.
[h=4]METHODS:[/h] Children aged 6-59 months presenting for emergency care (2008-2014) with an influenza-like illness were eligible. Influenza PCR/culture were performed on nasopharyngeal samples. Vaccination status was confirmed via the national register and/or vaccine providers. The test-negative design was used to estimate vaccine effectiveness (VE). Risk factors, parental attitudes and prescriber recommendations were assessed by parental questionnaire.
[h=4]RESULTS:[/h] 2723 children were recruited. Risk factors for severe disease included comorbid medical conditions (11.6%), preterm birth (13.0%) and indigeneity (5.0%). Influenza was identified in 546 (20.1%) participants. Overall VE (2008, 2010-2014) was 70.0% (95%CI: 47.7,82.9); VE for children with medical comorbidities, children born preterm, and children <2 years were 82.5% (14.6,96.4), 79.2% (10.9,95.1) and 84.7% (49.6,95.3) respectively. Following adverse events in 2010, the number of children fully vaccinated with TIV declined significantly. This included children with and without risk factors for severe disease. Attitudes were similar in parents of children with and without risk factors for severe disease.
[h=4]CONCLUSIONS:[/h] VE for TIV in young children with and without risk factors for severe disease was ≥70%. Despite this, participation in the preschool influenza vaccination program remains low with parents and prescribers unconvinced of the benefits and safety of TIV.
PMID: 26646548 [PubMed - as supplied by publisher]