tetano
Editor, Senior Moderator
Hum Vaccin Immunother. 2017 May 8:0. doi: 10.1080/21645515.2017.1321722. [Epub ahead of print]
[h=1]Influenza vaccine effectiveness among high-risk groups: a systematic literature review and meta-analysis of case-control and cohort studies.[/h] Restivo V[SUP]1[/SUP], Costantino C[SUP]1[/SUP], Bono S[SUP]1[/SUP], Maniglia M[SUP]1[/SUP], Marchese V[SUP]1[/SUP], Ventura G[SUP]1[/SUP], Casuccio A[SUP]1[/SUP], Tramuto F[SUP]1[/SUP], Vitale F[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Vaccination represents the most effective intervention to prevent infection, hospitalization and mortality due to influenza. This meta-analysis quantifies data reporting influenza vaccine effectiveness (VE) on influenza visits and hospitalizations of case-control and cohort studies among high-risk groups. A systematic literature review including original articles published between 2007 and 2016, using a protocol registered on Prospero with No. 42017054854, and a meta-analysis were conducted. For three high-risk groups (subjects with underlying health conditions, pregnant women and health care workers) only a qualitative evaluation was carried out. The VE quantitative analysis demonstrated a clear significant overall effect of 39% (95%CI: 32%-46%) for visits and 57% (95%CI: 30%-74%) for hospitalization among children. Considering the elderly influenza VE had a clear effect of 25% (95%CI: 6%-40%) for visits and 14% (95%CI: 7%-21%; p<0.001) for hospitalization. This study showed the high VE of influenza vaccination among high-risk groups, representing a tool for public health decision-makers to develop evidence-based preventive interventions to avoid influenza outcomes.
[h=4]KEYWORDS:[/h] ALRI = influenza-associated acute lower respiratory infections; GP = general practitioner; HCW = Health Care Worker; ILI = influenza-like illness; Influenza; OR = Odds ratio; RR = Relative risk; SLR = systematic literature review; SOT = solid organ transplant; VE = vaccine effectiveness; WHO = World Health Organization; children; chronic disease; effectiveness; elderly subjects; health care worker; hospitalization; pregnancy; vaccine; visit
PMID: 28481673 DOI: 10.1080/21645515.2017.1321722
[h=1]Influenza vaccine effectiveness among high-risk groups: a systematic literature review and meta-analysis of case-control and cohort studies.[/h] Restivo V[SUP]1[/SUP], Costantino C[SUP]1[/SUP], Bono S[SUP]1[/SUP], Maniglia M[SUP]1[/SUP], Marchese V[SUP]1[/SUP], Ventura G[SUP]1[/SUP], Casuccio A[SUP]1[/SUP], Tramuto F[SUP]1[/SUP], Vitale F[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Vaccination represents the most effective intervention to prevent infection, hospitalization and mortality due to influenza. This meta-analysis quantifies data reporting influenza vaccine effectiveness (VE) on influenza visits and hospitalizations of case-control and cohort studies among high-risk groups. A systematic literature review including original articles published between 2007 and 2016, using a protocol registered on Prospero with No. 42017054854, and a meta-analysis were conducted. For three high-risk groups (subjects with underlying health conditions, pregnant women and health care workers) only a qualitative evaluation was carried out. The VE quantitative analysis demonstrated a clear significant overall effect of 39% (95%CI: 32%-46%) for visits and 57% (95%CI: 30%-74%) for hospitalization among children. Considering the elderly influenza VE had a clear effect of 25% (95%CI: 6%-40%) for visits and 14% (95%CI: 7%-21%; p<0.001) for hospitalization. This study showed the high VE of influenza vaccination among high-risk groups, representing a tool for public health decision-makers to develop evidence-based preventive interventions to avoid influenza outcomes.
[h=4]KEYWORDS:[/h] ALRI = influenza-associated acute lower respiratory infections; GP = general practitioner; HCW = Health Care Worker; ILI = influenza-like illness; Influenza; OR = Odds ratio; RR = Relative risk; SLR = systematic literature review; SOT = solid organ transplant; VE = vaccine effectiveness; WHO = World Health Organization; children; chronic disease; effectiveness; elderly subjects; health care worker; hospitalization; pregnancy; vaccine; visit
PMID: 28481673 DOI: 10.1080/21645515.2017.1321722