tetano
Editor, Senior Moderator
J Infect Dis. 2016 Jan 6. pii: jiv577. [Epub ahead of print]
[h=1]Influenza Vaccine Effectiveness Against 2009 Pandemic Influenza A(H1N1) Virus Differed by Vaccine Type During 2013-2014 in the United States.[/h] Gaglani M[SUP]1[/SUP], Pruszynski J[SUP]1[/SUP], Murthy K[SUP]1[/SUP], Clipper L[SUP]1[/SUP], Robertson A[SUP]1[/SUP], Reis M[SUP]1[/SUP], Chung JR[SUP]2[/SUP], Piedra PA[SUP]3[/SUP], Avadhanula V[SUP]3[/SUP], Nowalk MP[SUP]4[/SUP], Zimmerman RK[SUP]4[/SUP], Jackson ML[SUP]5[/SUP], Jackson LA[SUP]5[/SUP], Petrie JG[SUP]6[/SUP], Ohmit SE[SUP]6[/SUP], Monto AS[SUP]6[/SUP], McLean HQ[SUP]7[/SUP], Belongia EA[SUP]7[/SUP], Fry AM[SUP]2[/SUP], Flannery B[SUP]2[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] The predominant strain during the 2013-2014 influenza season was 2009 pandemic influenza A(H1N1) virus (A[H1N1]pdm09). This vaccine-component has remained unchanged from 2009.
[h=4]METHODS:[/h] The US Flu Vaccine Effectiveness Network enrolled subjects aged ≥6 months with medically attended acute respiratory illness (MAARI), including cough, with illness onset ≤7 days before enrollment. Influenza was confirmed by reverse-transcription polymerase chain reaction (RT-PCR). We determined the effectiveness of trivalent or quadrivalent inactivated influenza vaccine (IIV) among subjects ages ≥6 months and the effectiveness of quadrivalent live attenuated influenza vaccine (LAIV4) among children aged 2-17 years, using a test-negative design. The effect of prior receipt of any A(H1N1)pdm09-containing vaccine since 2009 on the effectiveness of current-season vaccine was assessed.
[h=4]RESULTS:[/h] We enrolled 5999 subjects; 5637 (94%) were analyzed; 18% had RT-PCR-confirmed A(H1N1)pdm09-related MAARI. Overall, the effectiveness of vaccine against A(H1N1)pdm09-related MAARI was 54% (95% confidence interval [CI], 46%-61%). Among fully vaccinated children aged 2-17 years, the effectiveness of LAIV4 was 17% (95% CI, -39% to 51%) and the effectiveness of IIV was 60% (95% CI, 36%-74%). Subjects aged ≥9 years showed significant residual protection of any prior A(H1N1)pdm09-containing vaccine dose(s) received since 2009, as did children <9 years old considered fully vaccinated by prior season.
[h=4]CONCLUSIONS:[/h] During 2013-2014, IIV was significantly effective against A(H1N1)pdm09. Lack of LAIV4 effectiveness in children highlights the importance of continued annual monitoring of effectiveness of influenza vaccines in the United States.
? The Author 2016. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail journals.permissions@oup.com.
[h=4]KEYWORDS:[/h] influenza; influenza vaccine; influenza vaccine effectiveness; vaccine effectiveness
PMID: 26743842 [PubMed - as supplied by publisher]
[h=1]Influenza Vaccine Effectiveness Against 2009 Pandemic Influenza A(H1N1) Virus Differed by Vaccine Type During 2013-2014 in the United States.[/h] Gaglani M[SUP]1[/SUP], Pruszynski J[SUP]1[/SUP], Murthy K[SUP]1[/SUP], Clipper L[SUP]1[/SUP], Robertson A[SUP]1[/SUP], Reis M[SUP]1[/SUP], Chung JR[SUP]2[/SUP], Piedra PA[SUP]3[/SUP], Avadhanula V[SUP]3[/SUP], Nowalk MP[SUP]4[/SUP], Zimmerman RK[SUP]4[/SUP], Jackson ML[SUP]5[/SUP], Jackson LA[SUP]5[/SUP], Petrie JG[SUP]6[/SUP], Ohmit SE[SUP]6[/SUP], Monto AS[SUP]6[/SUP], McLean HQ[SUP]7[/SUP], Belongia EA[SUP]7[/SUP], Fry AM[SUP]2[/SUP], Flannery B[SUP]2[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] The predominant strain during the 2013-2014 influenza season was 2009 pandemic influenza A(H1N1) virus (A[H1N1]pdm09). This vaccine-component has remained unchanged from 2009.
[h=4]METHODS:[/h] The US Flu Vaccine Effectiveness Network enrolled subjects aged ≥6 months with medically attended acute respiratory illness (MAARI), including cough, with illness onset ≤7 days before enrollment. Influenza was confirmed by reverse-transcription polymerase chain reaction (RT-PCR). We determined the effectiveness of trivalent or quadrivalent inactivated influenza vaccine (IIV) among subjects ages ≥6 months and the effectiveness of quadrivalent live attenuated influenza vaccine (LAIV4) among children aged 2-17 years, using a test-negative design. The effect of prior receipt of any A(H1N1)pdm09-containing vaccine since 2009 on the effectiveness of current-season vaccine was assessed.
[h=4]RESULTS:[/h] We enrolled 5999 subjects; 5637 (94%) were analyzed; 18% had RT-PCR-confirmed A(H1N1)pdm09-related MAARI. Overall, the effectiveness of vaccine against A(H1N1)pdm09-related MAARI was 54% (95% confidence interval [CI], 46%-61%). Among fully vaccinated children aged 2-17 years, the effectiveness of LAIV4 was 17% (95% CI, -39% to 51%) and the effectiveness of IIV was 60% (95% CI, 36%-74%). Subjects aged ≥9 years showed significant residual protection of any prior A(H1N1)pdm09-containing vaccine dose(s) received since 2009, as did children <9 years old considered fully vaccinated by prior season.
[h=4]CONCLUSIONS:[/h] During 2013-2014, IIV was significantly effective against A(H1N1)pdm09. Lack of LAIV4 effectiveness in children highlights the importance of continued annual monitoring of effectiveness of influenza vaccines in the United States.
? The Author 2016. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved. For permissions, e-mail journals.permissions@oup.com.
[h=4]KEYWORDS:[/h] influenza; influenza vaccine; influenza vaccine effectiveness; vaccine effectiveness
PMID: 26743842 [PubMed - as supplied by publisher]