tetano
Editor, Senior Moderator
J Immunother Cancer. 2018 May 22;6(1):40. doi: 10.1186/s40425-018-0353-7.
[h=1]Influenza vaccination of cancer patients during PD-1 blockade induces serological protection but may raise the risk for immune-related adverse events.[/h] L?ubli H[SUP]1,[/SUP][SUP]2[/SUP], Balmelli C[SUP]1[/SUP], Kaufmann L[SUP]3[/SUP], Stanczak M[SUP]2[/SUP], Syedbasha M[SUP]3[/SUP], Vogt D[SUP]3[/SUP], Hertig A[SUP]1[/SUP], M?ller B[SUP]4[/SUP], Gautschi O[SUP]4[/SUP], Stenner F[SUP]1,[/SUP][SUP]2[/SUP], Zippelius A[SUP]1,[/SUP][SUP]2[/SUP], Egli A[SUP]3,[/SUP][SUP]5[/SUP], Rothschild SI[SUP]6,[/SUP][SUP]7[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] Immune checkpoint inhibiting antibodies were introduced into routine clinical practice for cancer patients. Checkpoint blockade has led to durable remissions in some patients, but may also induce immune-related adverse events (irAEs). Lung cancer patients show an increased risk for complications, when infected with influenza viruses. Therefore, vaccination is recommended. However, the efficacy and safety of influenza vaccination during checkpoint blockade and its influence on irAEs is unclear. Similarly, the influence of vaccinations on T cell-mediated immune reactions in patients during PD-1 blockade remains poorly defined.
[h=4]METHODS:[/h] We vaccinated 23 lung cancer patients and 11 age-matched healthy controls using a trivalent inactivated influenza vaccine to investigate vaccine-induced immunity and safety during checkpoint blockade.
[h=4]RESULTS:[/h] We did not observe significant differences between patients and healthy controls in vaccine-induced antibody titers against all three viral antigens. Influenza vaccination resulted in protective titers in more than 60% of patients/participants. In cancer patients, the post-vaccine frequency of irAEs was 52.2% with a median time to occurrence of 3.2 months after vaccination. Six of 23 patients (26.1%) showed severe grade 3/4 irAEs. This frequency of irAEs might be higher than the rate previously published in the literature and the rate observed in a non-study population at our institution (all grades 25.5%, grade 3/4 9.8%).
[h=4]CONCLUSIONS:[/h] Although this is a non-randomized trial with a limited number of patients, the increased rate of immunological toxicity is concerning. This finding should be studied in a larger patient population.
[h=4]KEYWORDS:[/h] Cancer immunotherapy; Checkpoint inhibitor; Immune-related adverse events (irAE); Influenza vaccine; Vaccine response
PMID: 29789020 PMCID: PMC5964701 DOI: 10.1186/s40425-018-0353-7
[h=1]Influenza vaccination of cancer patients during PD-1 blockade induces serological protection but may raise the risk for immune-related adverse events.[/h] L?ubli H[SUP]1,[/SUP][SUP]2[/SUP], Balmelli C[SUP]1[/SUP], Kaufmann L[SUP]3[/SUP], Stanczak M[SUP]2[/SUP], Syedbasha M[SUP]3[/SUP], Vogt D[SUP]3[/SUP], Hertig A[SUP]1[/SUP], M?ller B[SUP]4[/SUP], Gautschi O[SUP]4[/SUP], Stenner F[SUP]1,[/SUP][SUP]2[/SUP], Zippelius A[SUP]1,[/SUP][SUP]2[/SUP], Egli A[SUP]3,[/SUP][SUP]5[/SUP], Rothschild SI[SUP]6,[/SUP][SUP]7[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] Immune checkpoint inhibiting antibodies were introduced into routine clinical practice for cancer patients. Checkpoint blockade has led to durable remissions in some patients, but may also induce immune-related adverse events (irAEs). Lung cancer patients show an increased risk for complications, when infected with influenza viruses. Therefore, vaccination is recommended. However, the efficacy and safety of influenza vaccination during checkpoint blockade and its influence on irAEs is unclear. Similarly, the influence of vaccinations on T cell-mediated immune reactions in patients during PD-1 blockade remains poorly defined.
[h=4]METHODS:[/h] We vaccinated 23 lung cancer patients and 11 age-matched healthy controls using a trivalent inactivated influenza vaccine to investigate vaccine-induced immunity and safety during checkpoint blockade.
[h=4]RESULTS:[/h] We did not observe significant differences between patients and healthy controls in vaccine-induced antibody titers against all three viral antigens. Influenza vaccination resulted in protective titers in more than 60% of patients/participants. In cancer patients, the post-vaccine frequency of irAEs was 52.2% with a median time to occurrence of 3.2 months after vaccination. Six of 23 patients (26.1%) showed severe grade 3/4 irAEs. This frequency of irAEs might be higher than the rate previously published in the literature and the rate observed in a non-study population at our institution (all grades 25.5%, grade 3/4 9.8%).
[h=4]CONCLUSIONS:[/h] Although this is a non-randomized trial with a limited number of patients, the increased rate of immunological toxicity is concerning. This finding should be studied in a larger patient population.
[h=4]KEYWORDS:[/h] Cancer immunotherapy; Checkpoint inhibitor; Immune-related adverse events (irAE); Influenza vaccine; Vaccine response
PMID: 29789020 PMCID: PMC5964701 DOI: 10.1186/s40425-018-0353-7
