tetano
Editor, Senior Moderator
Ned Tijdschr Geneeskd. 2014;158(0):A7574.
[Influenza vaccination in immunocompromised patients].
[Article in Dutch]
Klinkenberg RE1, Gelinck LB.
Author information
Abstract
- Immunocompromised patients are extra sensitive to serious influenza infections.- A compromised immune system in these patients also results in an impaired immune response following influenza vaccination.- Recently, many vaccination studies have been carried out in patients with HIV, patients treated with rituximab or a tumour necrosis factor (TNF)-alpha blocker, patients with malignancies, and in patients following allogeneic stem cell transplantation for haematological malignancy or following solid organ transplantation.- In most patient groups influenza vaccination induces a sufficiently high antibody titre.- Patients using rituximab, patients who recently received a stem cell transplantation and patients treated with active cytotoxic chemotherapy may show an insufficient antibody response following influenza vaccination.- In general, adapted vaccination strategies such as repeated administration of a vaccine or administering a higher dose of vaccine antigen results in a better immune response following vaccination.- Therefore, influenza vaccination is recommended for all patient groups.
PMID:
24988164
[PubMed - in process]
http://www.ncbi.nlm.nih.gov/pubmed/24988164
[Influenza vaccination in immunocompromised patients].
[Article in Dutch]
Klinkenberg RE1, Gelinck LB.
Author information
Abstract
- Immunocompromised patients are extra sensitive to serious influenza infections.- A compromised immune system in these patients also results in an impaired immune response following influenza vaccination.- Recently, many vaccination studies have been carried out in patients with HIV, patients treated with rituximab or a tumour necrosis factor (TNF)-alpha blocker, patients with malignancies, and in patients following allogeneic stem cell transplantation for haematological malignancy or following solid organ transplantation.- In most patient groups influenza vaccination induces a sufficiently high antibody titre.- Patients using rituximab, patients who recently received a stem cell transplantation and patients treated with active cytotoxic chemotherapy may show an insufficient antibody response following influenza vaccination.- In general, adapted vaccination strategies such as repeated administration of a vaccine or administering a higher dose of vaccine antigen results in a better immune response following vaccination.- Therefore, influenza vaccination is recommended for all patient groups.
PMID:
24988164
[PubMed - in process]
http://www.ncbi.nlm.nih.gov/pubmed/24988164