tetano
Editor, Senior Moderator
Pediatr Infect Dis J. 2013 Sep 20. [Epub ahead of print]
Influenza Vaccination Given at Least 2 Weeks before Delivery to Pregnant Women Facilitates Transmission of Seroprotective Influenza-Specific Antibodies to the Newborn.
Rohner GB, Meier S, Bel M, Combescure C, Othenin-Girard V, Swali RA, de Tejada BM, Siegrist CA.
Source
1. Department of Pediatrics, Children's Hospital of Geneva, University Hospitals of Geneva and Faculty of Medicine, Geneva, Switzerland 2. Center for Vaccinology and Neonatal Immunology, Department of Pediatrics and Pathology-Immunology, Medical Faculty and University Hospitals of Geneva, Switzerland 3. Clinical Research Center, University Hospitals of Geneva & Faculty of Medicine, University of Geneva, Switzerland 4. Department of Gynecology and Obstetrics, University Hospitals of Geneva, Switzerland and Faculty of Medicine, Geneva, Switzerland 5. Laboratory of Virology, Department of Genetics and Laboratory Medicine, University Hospitals of Geneva and Faculty of Medicine, University of Geneva, Geneva, Switzerland.
Abstract
INTRODUCTION::
Pregnant women and infants are at higher risk of complications secondary to influenza infection. Immunization during pregnancy facilitates protection of the neonates through passive transfer of maternal antibodies.
METHODS::
This was a cross-sectional study performed during the post-H1N1 pandemic winter season of 2010/2011 in Geneva, Switzerland. We measured antibody titers against the seasonal influenza A H1N1, H3N2 and B 2010/2011 strains by hemagglutination inhibition (HAI) in the umbilical cord blood of newborns born to vaccinated and non-vaccinated mothers. Seroprotection was defined as a HAI titer ≥ 40.
RESULTS::
A total of 188 women were enrolled, 101 of whom had been vaccinated with a non-adjuvanted influenza vaccine (all during the second or third trimester) and 87 had not. Among newborns of vaccinated women, 84-86% showed seroprotective levels depending on the strain. In comparison, seroprotection rates were significantly lower in babies of non-vaccinated women (29-33%, p<0.001). Adjusting for various confounding factors and applying multivariate regression analysis, vaccination during pregnancy 2 weeks or more before delivery increased geometric mean titers (GMT) in umbilical cord blood 5 to 17 times and seroprotection rates 5.8 to 34.4 times depending on the strain and the interval between vaccination and delivery. Vaccinating pregnant women only 2-4 weeks before delivery was still more effective than no vaccination at all (GMTs increased 6.8-11.1 times and seroprotection rates increased 5.8-34.4 times compared to non-vaccinated women).
CONCLUSION::
Influenza vaccination at any time during the second and third trimester of pregnancy, but at least 15 days before delivery, confers seroprotection to the majority of neonates.
PMID:
24061270
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/24061270
Influenza Vaccination Given at Least 2 Weeks before Delivery to Pregnant Women Facilitates Transmission of Seroprotective Influenza-Specific Antibodies to the Newborn.
Rohner GB, Meier S, Bel M, Combescure C, Othenin-Girard V, Swali RA, de Tejada BM, Siegrist CA.
Source
1. Department of Pediatrics, Children's Hospital of Geneva, University Hospitals of Geneva and Faculty of Medicine, Geneva, Switzerland 2. Center for Vaccinology and Neonatal Immunology, Department of Pediatrics and Pathology-Immunology, Medical Faculty and University Hospitals of Geneva, Switzerland 3. Clinical Research Center, University Hospitals of Geneva & Faculty of Medicine, University of Geneva, Switzerland 4. Department of Gynecology and Obstetrics, University Hospitals of Geneva, Switzerland and Faculty of Medicine, Geneva, Switzerland 5. Laboratory of Virology, Department of Genetics and Laboratory Medicine, University Hospitals of Geneva and Faculty of Medicine, University of Geneva, Geneva, Switzerland.
Abstract
INTRODUCTION::
Pregnant women and infants are at higher risk of complications secondary to influenza infection. Immunization during pregnancy facilitates protection of the neonates through passive transfer of maternal antibodies.
METHODS::
This was a cross-sectional study performed during the post-H1N1 pandemic winter season of 2010/2011 in Geneva, Switzerland. We measured antibody titers against the seasonal influenza A H1N1, H3N2 and B 2010/2011 strains by hemagglutination inhibition (HAI) in the umbilical cord blood of newborns born to vaccinated and non-vaccinated mothers. Seroprotection was defined as a HAI titer ≥ 40.
RESULTS::
A total of 188 women were enrolled, 101 of whom had been vaccinated with a non-adjuvanted influenza vaccine (all during the second or third trimester) and 87 had not. Among newborns of vaccinated women, 84-86% showed seroprotective levels depending on the strain. In comparison, seroprotection rates were significantly lower in babies of non-vaccinated women (29-33%, p<0.001). Adjusting for various confounding factors and applying multivariate regression analysis, vaccination during pregnancy 2 weeks or more before delivery increased geometric mean titers (GMT) in umbilical cord blood 5 to 17 times and seroprotection rates 5.8 to 34.4 times depending on the strain and the interval between vaccination and delivery. Vaccinating pregnant women only 2-4 weeks before delivery was still more effective than no vaccination at all (GMTs increased 6.8-11.1 times and seroprotection rates increased 5.8-34.4 times compared to non-vaccinated women).
CONCLUSION::
Influenza vaccination at any time during the second and third trimester of pregnancy, but at least 15 days before delivery, confers seroprotection to the majority of neonates.
PMID:
24061270
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/24061270