tetano
Editor, Senior Moderator
Clin Respir J. 2013 Sep 23. doi: 10.1111/crj.12056. [Epub ahead of print]
Influenza pneumonia among adolescents and adults: a concurrent comparison between influenza A (H1N1) pdm09 and A (H3N2) in the post pandemic period.
Yang SQ, Qu JX, Wang C, Yu XM, Liu YM, Cao B.
Source
Department of Infectious Diseases and Clinical Microbiology, Beijing Chao-Yang Hospital, Beijing Institute of Respiratory Medicine, Capital Medical University, Beijing, China.
Abstract
INTRODUCTION:
Comparisons of the characteristics between the influenza A (H1N1) pdm09 and common seasonal influenza are important for both clinical management and epidemiological studies. However, the differences between pandemic and seasonal influenza during the post-pandemic period are poorly understood.
OBJECTIVES:
The aim of our research was to investigate clinical and immune response differences between patients with influenza A (H1N1) pdm09 pneumonia and seasonal influenza A (H3N2) pneumonia in the post-pandemic period.
METHODS:
During the first flu season in post-pandemic period, patients from Beijing Network for Adult Community-Acquired Pneumonia (BNACAP) present A (H1N1) pdm09 or A (H3N2) influenza were compared concurrently in the aspects of clinical charactristics and inflammatory profile in acute phase.
RESULT:
Patients with A (H1N1) pdm09 influenza pneumonia showed a close mean age to A (H3N2) pneumonia (51?20 versus 53?16 Mean?SD, years) but tended to have more underlying diseases (32.8% versus 10%, p=0.036). Though clinical characteristics were similar, no statistical difference were found in PSI score or ICU admission rate or mortality, patients in A (H1N1) pdm09 cohort present higher levels of aspartate aminotransferase (AST), lactase dehydrogenase (LDH) (p=0.006, 0.018, respectively) in blood, and also longer duration of fever than A (H3N2) cohort. Levels of IL-10, IL-12 (p70) were higher in A (H1N1) pdm09 cohort (p=0.031, 0.047, respectively).
CONCLUSIOS:
During the first post-pandemic flu season, patients with the A (H1N1) pdm09 pneumonia showed similar clinical characteristics but slightly higher disease severity and stronger systemic inflammatory response than A (H3N2) pneumonia.
This article is protected by copyright. All rights reserved.
KEYWORDS:
Influenza A (H1N1) pdm09 , pneumonia, post-pandemic, seasonal influenza A (H3N2)
PMID:
24106842
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/24106842
Influenza pneumonia among adolescents and adults: a concurrent comparison between influenza A (H1N1) pdm09 and A (H3N2) in the post pandemic period.
Yang SQ, Qu JX, Wang C, Yu XM, Liu YM, Cao B.
Source
Department of Infectious Diseases and Clinical Microbiology, Beijing Chao-Yang Hospital, Beijing Institute of Respiratory Medicine, Capital Medical University, Beijing, China.
Abstract
INTRODUCTION:
Comparisons of the characteristics between the influenza A (H1N1) pdm09 and common seasonal influenza are important for both clinical management and epidemiological studies. However, the differences between pandemic and seasonal influenza during the post-pandemic period are poorly understood.
OBJECTIVES:
The aim of our research was to investigate clinical and immune response differences between patients with influenza A (H1N1) pdm09 pneumonia and seasonal influenza A (H3N2) pneumonia in the post-pandemic period.
METHODS:
During the first flu season in post-pandemic period, patients from Beijing Network for Adult Community-Acquired Pneumonia (BNACAP) present A (H1N1) pdm09 or A (H3N2) influenza were compared concurrently in the aspects of clinical charactristics and inflammatory profile in acute phase.
RESULT:
Patients with A (H1N1) pdm09 influenza pneumonia showed a close mean age to A (H3N2) pneumonia (51?20 versus 53?16 Mean?SD, years) but tended to have more underlying diseases (32.8% versus 10%, p=0.036). Though clinical characteristics were similar, no statistical difference were found in PSI score or ICU admission rate or mortality, patients in A (H1N1) pdm09 cohort present higher levels of aspartate aminotransferase (AST), lactase dehydrogenase (LDH) (p=0.006, 0.018, respectively) in blood, and also longer duration of fever than A (H3N2) cohort. Levels of IL-10, IL-12 (p70) were higher in A (H1N1) pdm09 cohort (p=0.031, 0.047, respectively).
CONCLUSIOS:
During the first post-pandemic flu season, patients with the A (H1N1) pdm09 pneumonia showed similar clinical characteristics but slightly higher disease severity and stronger systemic inflammatory response than A (H3N2) pneumonia.
This article is protected by copyright. All rights reserved.
KEYWORDS:
Influenza A (H1N1) pdm09 , pneumonia, post-pandemic, seasonal influenza A (H3N2)
PMID:
24106842
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/24106842