tetano
Editor, Senior Moderator
Influenza Other Respir Viruses
. 2024 Nov;18(11):e70032.
doi: 10.1111/irv.70032. The Burden of Seasonal Influenza and Its Potential Complications Among Older Japanese Adults: A Real-World Database Study
Takeshi Arashiro[SUP] 1 [/SUP], Yuki Tajima[SUP] 2 [/SUP], Yohei Ban[SUP] 3 [/SUP], Matthew M Loiacono[SUP] 4 [/SUP], Masayo Ideguchi[SUP] 5 [/SUP], Caroline de Courville[SUP] 6 [/SUP]
Affiliations
Background: Seasonal influenza may lead to severe complications, including respiratory and cardiovascular disease, that result in considerable healthcare resource utilization (HCRU) and mortality, particularly in older individuals. This real-world study assessed the burden of influenza and its potential complications in older Japanese adults.
Methods: This retrospective claims database analysis (April 2015 to June 2019) included insured individuals aged ≥ 60 years at the start of four consecutive influenza seasons in Japan (October 1 to April 30). The primary endpoint was the incidence of influenza-related emergency room (ER) and outpatient visits, the incidence of hospitalizations, the probability of 30-day inpatient mortality, and 60-day medical costs of influenza or its potential complications.
Results: Of 8,974,708 individuals (43.2% male, mean ± standard deviation age 73.8 ± 8.9 years), 370,430 (4.13%) were diagnosed with influenza. Overall, 17.18 (95% confidence interval [CI] 16.32-18.04) and 3893.53 (3880.87-3906.19) per 100,000 individuals had influenza-related ER and outpatient visits, respectively, and 181.50 (178.71-184.28) per 100,000 individuals were hospitalized for influenza. The incidence of influenza-related ER visits and hospitalizations for influenza or potential complications and the probability of 30-day inpatient mortality increased with age.
Conclusions: Seasonal influenza and its potential complications represent a substantial burden that increases with age in Japanese individuals.
Keywords: Japan; aged; healthcare costs; hospitalization; human; influenza; mortality.
. 2024 Nov;18(11):e70032.
doi: 10.1111/irv.70032. The Burden of Seasonal Influenza and Its Potential Complications Among Older Japanese Adults: A Real-World Database Study
Takeshi Arashiro[SUP] 1 [/SUP], Yuki Tajima[SUP] 2 [/SUP], Yohei Ban[SUP] 3 [/SUP], Matthew M Loiacono[SUP] 4 [/SUP], Masayo Ideguchi[SUP] 5 [/SUP], Caroline de Courville[SUP] 6 [/SUP]
Affiliations
- PMID: 39533850
- PMCID: PMC11557991
- DOI: 10.1111/irv.70032
Background: Seasonal influenza may lead to severe complications, including respiratory and cardiovascular disease, that result in considerable healthcare resource utilization (HCRU) and mortality, particularly in older individuals. This real-world study assessed the burden of influenza and its potential complications in older Japanese adults.
Methods: This retrospective claims database analysis (April 2015 to June 2019) included insured individuals aged ≥ 60 years at the start of four consecutive influenza seasons in Japan (October 1 to April 30). The primary endpoint was the incidence of influenza-related emergency room (ER) and outpatient visits, the incidence of hospitalizations, the probability of 30-day inpatient mortality, and 60-day medical costs of influenza or its potential complications.
Results: Of 8,974,708 individuals (43.2% male, mean ± standard deviation age 73.8 ± 8.9 years), 370,430 (4.13%) were diagnosed with influenza. Overall, 17.18 (95% confidence interval [CI] 16.32-18.04) and 3893.53 (3880.87-3906.19) per 100,000 individuals had influenza-related ER and outpatient visits, respectively, and 181.50 (178.71-184.28) per 100,000 individuals were hospitalized for influenza. The incidence of influenza-related ER visits and hospitalizations for influenza or potential complications and the probability of 30-day inpatient mortality increased with age.
Conclusions: Seasonal influenza and its potential complications represent a substantial burden that increases with age in Japanese individuals.
Keywords: Japan; aged; healthcare costs; hospitalization; human; influenza; mortality.