tetano
Editor, Senior Moderator
Influenza Other Respir Viruses
. 2020 May 25.
doi: 10.1111/irv.12754. Online ahead of print.
Severity and Mortality of Respiratory Syncytial Virus vs Influenza A Infection in Hospitalized Adults in China
Yulin Zhang[SUP] 1 [/SUP], Yeming Wang[SUP] 1 [/SUP], Jiankang Zhao[SUP] 1 [/SUP], Zhujia Xiong[SUP] 1 [/SUP], Yanyan Fan[SUP] 1 [/SUP], Wang Zhang[SUP] 1 [/SUP], Xiaohui Zou[SUP] 1 [/SUP], Chunlei Wang[SUP] 1 [/SUP], Jiajing Han[SUP] 1 [/SUP], Binbin Li[SUP] 1 [/SUP], Binghuai Lu, Bin Cao[SUP] 1 2 3 [/SUP], CAP-China Network
Affiliations
Abstract
Background: Respiratory syncytial virus (RSV) is an important cause of medically attended acute respiratory illnesses in older adults but awareness of the relevance of RSV in older people remains lower than that of influenza, which exhibits similar clinical characteristics to those of RSV.
Objectives: This study was performed to assess the clinical significance of RSV in respiratory samples from hospitalized adults.
Methods: Characteristics and outcomes in adults (≥18 years) hospitalized for RSV infection (n = 51) were compared with a cohort hospitalized for influenza A infection (n = 279) in a single-center retrospective cohort study in Beijing, China.
Results: Respiratory syncytial virus patients were slightly older, with no significant differences in underlying chronic conditions. Lower respiratory tract infection and cardiovascular complications were more frequent (P < .05) in RSV patients. Rates of mortality in the RSV cohorts were significantly higher within 30 days (13.7% vs 5.0%, P = .019) and 60 days (17.6% vs 7.5%, P = .021). Bacterial co-infection in respiratory samples was associated with reduced survival among RSV patients (log rank, P = .013).
Conclusions: Respiratory syncytial virus is a common cause of serious illness among hospitalized adults in China with greater mortality than influenza A. Increased awareness and the availability of antiviral agents might increase the scope for successful management.
Keywords: bacterial co-infection; cardiovascular complications; in-hospital mortality; viral infection.
? 2020 The Authors. Influenza and Other Respiratory Viruses Published by John Wiley & Sons Ltd.
. 2020 May 25.
doi: 10.1111/irv.12754. Online ahead of print.
Severity and Mortality of Respiratory Syncytial Virus vs Influenza A Infection in Hospitalized Adults in China
Yulin Zhang[SUP] 1 [/SUP], Yeming Wang[SUP] 1 [/SUP], Jiankang Zhao[SUP] 1 [/SUP], Zhujia Xiong[SUP] 1 [/SUP], Yanyan Fan[SUP] 1 [/SUP], Wang Zhang[SUP] 1 [/SUP], Xiaohui Zou[SUP] 1 [/SUP], Chunlei Wang[SUP] 1 [/SUP], Jiajing Han[SUP] 1 [/SUP], Binbin Li[SUP] 1 [/SUP], Binghuai Lu, Bin Cao[SUP] 1 2 3 [/SUP], CAP-China Network
Affiliations
- PMID: 32449300
- DOI: 10.1111/irv.12754
Abstract
Background: Respiratory syncytial virus (RSV) is an important cause of medically attended acute respiratory illnesses in older adults but awareness of the relevance of RSV in older people remains lower than that of influenza, which exhibits similar clinical characteristics to those of RSV.
Objectives: This study was performed to assess the clinical significance of RSV in respiratory samples from hospitalized adults.
Methods: Characteristics and outcomes in adults (≥18 years) hospitalized for RSV infection (n = 51) were compared with a cohort hospitalized for influenza A infection (n = 279) in a single-center retrospective cohort study in Beijing, China.
Results: Respiratory syncytial virus patients were slightly older, with no significant differences in underlying chronic conditions. Lower respiratory tract infection and cardiovascular complications were more frequent (P < .05) in RSV patients. Rates of mortality in the RSV cohorts were significantly higher within 30 days (13.7% vs 5.0%, P = .019) and 60 days (17.6% vs 7.5%, P = .021). Bacterial co-infection in respiratory samples was associated with reduced survival among RSV patients (log rank, P = .013).
Conclusions: Respiratory syncytial virus is a common cause of serious illness among hospitalized adults in China with greater mortality than influenza A. Increased awareness and the availability of antiviral agents might increase the scope for successful management.
Keywords: bacterial co-infection; cardiovascular complications; in-hospital mortality; viral infection.
? 2020 The Authors. Influenza and Other Respiratory Viruses Published by John Wiley & Sons Ltd.