tetano
Editor, Senior Moderator
Influenza Other Respir Viruses
. 2021 Apr 7.
doi: 10.1111/irv.12858. Online ahead of print.
Differentiating impacts of non-pharmaceutical interventions on non-coronavirus disease-2019 respiratory viral infections: Hospital-based retrospective observational study in Taiwan
Andrew Po-Liang Chen[SUP] 1 2 [/SUP], Isaac Yen-Hao Chu[SUP] 3 [/SUP], Mei-Lin Yeh[SUP] 4 [/SUP], Yin-Yin Chen[SUP] 5 6 [/SUP], Chia-Lin Lee[SUP] 7 [/SUP], Hsiao-Hsuan Lin[SUP] 7 [/SUP], Yu-Jiun Chan[SUP] 6 7 [/SUP], Hsin-Pai Chen[SUP] 1 8 [/SUP]
Affiliations
Abstract
Background: Physical distancing and facemask use are worldwide recognized as effective non-pharmaceutical interventions (NPIs) against the coronavirus disease-2019 (COVID-19). Since January 2020, Taiwan has introduced both NPIs but their effectiveness on non-COVID-19 respiratory viruses (NCRVs) remain underexplored.
Methods: This retrospective observational study examined electronic records at a tertiary hospital in northern Taiwan from pre-COVID (January-December 2019) to post-COVID period (January-May 2020). Patients with respiratory syndromes were tested for both enveloped (eg, influenza virus and seasonal coronavirus) and non-enveloped RVs (eg, enterovirus and rhinovirus) using multiplex reverse transcription polymerase chain reaction assays. Monthly positivity rates of NCRVs among adult and pediatric patients were analyzed with comparison between pre- and post-COVID periods.
Results: A total of 9693 patients underwent 12 127 multiplex RT-PCR tests. The average positivity rate of NCRVs reduced by 11.2% (25.6% to 14.4%) after nationwide PHIs. Despite the COVID-19 pandemic, the most commonly identified enveloped and non-enveloped viruses were influenza virus and enterovirus/rhinovirus, respectively. Observed reduction in NCRV incidence was predominantly contributed by enveloped NCRVs including influenza viruses. We did not observe epidemiological impacts of NPIs on non-enveloped viruses but an increasing trend in enterovirus/rhinovirus test positivity rate among pediatric patients. Our data were validated using Taiwan's national notification database.
Conclusions: Our frontline investigation suggests that the current NPIs in Taiwan might not effectively control the transmission of non-enveloped respiratory viruses, despite their protective effects against influenza and seasonal coronavirus. Health authorities may consider using hydrogen peroxide or chloride-based disinfectants as additional preventative strategies against non-enveloped respiratory viruses in the post-COVID-19 era.
Keywords: COVID-19 pandemic; Influenza virus; enterovirus; enveloped respiratory viruses; infection control; non-enveloped respiratory viruses; non-pharmaceutical intervention; seasonal coronavirus.
. 2021 Apr 7.
doi: 10.1111/irv.12858. Online ahead of print.
Differentiating impacts of non-pharmaceutical interventions on non-coronavirus disease-2019 respiratory viral infections: Hospital-based retrospective observational study in Taiwan
Andrew Po-Liang Chen[SUP] 1 2 [/SUP], Isaac Yen-Hao Chu[SUP] 3 [/SUP], Mei-Lin Yeh[SUP] 4 [/SUP], Yin-Yin Chen[SUP] 5 6 [/SUP], Chia-Lin Lee[SUP] 7 [/SUP], Hsiao-Hsuan Lin[SUP] 7 [/SUP], Yu-Jiun Chan[SUP] 6 7 [/SUP], Hsin-Pai Chen[SUP] 1 8 [/SUP]
Affiliations
- PMID: 33825310
- DOI: 10.1111/irv.12858
Abstract
Background: Physical distancing and facemask use are worldwide recognized as effective non-pharmaceutical interventions (NPIs) against the coronavirus disease-2019 (COVID-19). Since January 2020, Taiwan has introduced both NPIs but their effectiveness on non-COVID-19 respiratory viruses (NCRVs) remain underexplored.
Methods: This retrospective observational study examined electronic records at a tertiary hospital in northern Taiwan from pre-COVID (January-December 2019) to post-COVID period (January-May 2020). Patients with respiratory syndromes were tested for both enveloped (eg, influenza virus and seasonal coronavirus) and non-enveloped RVs (eg, enterovirus and rhinovirus) using multiplex reverse transcription polymerase chain reaction assays. Monthly positivity rates of NCRVs among adult and pediatric patients were analyzed with comparison between pre- and post-COVID periods.
Results: A total of 9693 patients underwent 12 127 multiplex RT-PCR tests. The average positivity rate of NCRVs reduced by 11.2% (25.6% to 14.4%) after nationwide PHIs. Despite the COVID-19 pandemic, the most commonly identified enveloped and non-enveloped viruses were influenza virus and enterovirus/rhinovirus, respectively. Observed reduction in NCRV incidence was predominantly contributed by enveloped NCRVs including influenza viruses. We did not observe epidemiological impacts of NPIs on non-enveloped viruses but an increasing trend in enterovirus/rhinovirus test positivity rate among pediatric patients. Our data were validated using Taiwan's national notification database.
Conclusions: Our frontline investigation suggests that the current NPIs in Taiwan might not effectively control the transmission of non-enveloped respiratory viruses, despite their protective effects against influenza and seasonal coronavirus. Health authorities may consider using hydrogen peroxide or chloride-based disinfectants as additional preventative strategies against non-enveloped respiratory viruses in the post-COVID-19 era.
Keywords: COVID-19 pandemic; Influenza virus; enterovirus; enveloped respiratory viruses; infection control; non-enveloped respiratory viruses; non-pharmaceutical intervention; seasonal coronavirus.