tetano
Editor, Senior Moderator
Influenza Other Respir Viruses
. 2026 Mar;20(3):e70250.
doi: 10.1111/irv.70250.
Cross-Reactive IgG Antibody Responses to SARS-CoV-2 in Older Adults Following Seasonal Coronavirus Infection in Jiangsu, China (2015-2017)
Cheng Xiao[SUP] 1 [/SUP], Nancy H L Leung[SUP] 2 [/SUP], Shiman Ling[SUP] 3 [/SUP], Xia Lin[SUP] 1 [/SUP], Yuyun Chen[SUP] 2 [/SUP], Yanmin Xie[SUP] 2 [/SUP], Malik Peiris[SUP] 4 [/SUP], Mark Zanin[SUP] 4 5 [/SUP], Benjamin Cowling[SUP] 2 [/SUP], Sook-San Wong[SUP] 1 [/SUP]
Affiliations
The extent of cross-reactive antibodies to SARS-CoV-2 elicited by seasonal human coronaviruses (HCoVs) remains unclear. We analyzed longitudinal preinfection and postinfection IgG responses in 62 older adults with PCR-confirmed HCoV infections from sera collected prior to the emergence of SARS-CoV-2. At baseline, 12.9% and 16.1% had low-titer antibodies against SARS-CoV-2 spike (S) or nucleocapsid (N) proteins, respectively, but postinfection increases were marginal. Our findings suggest seasonal HCoV infections induce limited SARS-CoV-2 cross-reactive antibodies in community-dwelling older adults.
. 2026 Mar;20(3):e70250.
doi: 10.1111/irv.70250.
Cross-Reactive IgG Antibody Responses to SARS-CoV-2 in Older Adults Following Seasonal Coronavirus Infection in Jiangsu, China (2015-2017)
Cheng Xiao[SUP] 1 [/SUP], Nancy H L Leung[SUP] 2 [/SUP], Shiman Ling[SUP] 3 [/SUP], Xia Lin[SUP] 1 [/SUP], Yuyun Chen[SUP] 2 [/SUP], Yanmin Xie[SUP] 2 [/SUP], Malik Peiris[SUP] 4 [/SUP], Mark Zanin[SUP] 4 5 [/SUP], Benjamin Cowling[SUP] 2 [/SUP], Sook-San Wong[SUP] 1 [/SUP]
Affiliations
- PMID: 41830176
- DOI: 10.1111/irv.70250
The extent of cross-reactive antibodies to SARS-CoV-2 elicited by seasonal human coronaviruses (HCoVs) remains unclear. We analyzed longitudinal preinfection and postinfection IgG responses in 62 older adults with PCR-confirmed HCoV infections from sera collected prior to the emergence of SARS-CoV-2. At baseline, 12.9% and 16.1% had low-titer antibodies against SARS-CoV-2 spike (S) or nucleocapsid (N) proteins, respectively, but postinfection increases were marginal. Our findings suggest seasonal HCoV infections induce limited SARS-CoV-2 cross-reactive antibodies in community-dwelling older adults.