tetano
Editor, Senior Moderator
Influenza Other Respir Viruses
. 2021 Jan 26.
doi: 10.1111/irv.12842. Online ahead of print.
Comparative incidence and burden of respiratory viruses associated with hospitalization in adults in New York City
William D Sieling[SUP] 1 [/SUP], Connor R Goldman[SUP] 1 [/SUP], Matthew Oberhardt[SUP] 2 [/SUP], Matthew Phillips[SUP] 3 [/SUP], Lyn Finelli[SUP] 3 [/SUP], Lisa Saiman[SUP] 1 4 [/SUP]
Affiliations
Abstract
Background: Although the burden of influenza is well characterized, the burden of community-onset non-influenza respiratory viruses has not been systematically assessed. Understanding the severity and seasonality of non-influenza viruses, including human coronaviruses, will provide a better understanding of the overall disease burden from respiratory viruses that could better inform resource utilization for hospitals and highlight the value of preventative strategies, including vaccines.
Methods: From October 2017 to September 2019, a retrospective study was performed in a pre-defined catchment area to estimate the population-based incidence of community-onset respiratory viruses associated with hospitalization. Included patients were ≥18 years old, resided in New York City, were hospitalized for ≥24 hours, and had a respiratory virus detected within 3 calendar-days of admission. Disease burden was measured by hospital length of stay (LOS), intensive care unit (ICU) admissions, and in-hospital mortality and compared among those with laboratory-confirmed influenza versus those with laboratory-confirmed non-influenza viruses (human coronaviruses, parainfluenza viruses, respiratory syncytial virus, human metapneumovirus, and adenovirus).
Results: During the study period, 4232 eligible patients were identified of whom 50.9% were ≥65 years of age. For each virus, the population-based incidence was highest for those ≥80 years of age. When compared to those with influenza viruses detected, those with non-influenza respiratory viruses detected (combined) had higher population-based incidence, significantly more ICU admissions, and higher in-house mortality.
Conclusions: The burden of non-influenza respiratory viruses for hospitalized adults is substantial. Prevention and treatment strategies are needed for non-influenza respiratory viruses, particularly for older adults.
Keywords: adenovirus; human coronaviruses; influenza; parainfluenza viruses; respiratory syncytial virus.
. 2021 Jan 26.
doi: 10.1111/irv.12842. Online ahead of print.
Comparative incidence and burden of respiratory viruses associated with hospitalization in adults in New York City
William D Sieling[SUP] 1 [/SUP], Connor R Goldman[SUP] 1 [/SUP], Matthew Oberhardt[SUP] 2 [/SUP], Matthew Phillips[SUP] 3 [/SUP], Lyn Finelli[SUP] 3 [/SUP], Lisa Saiman[SUP] 1 4 [/SUP]
Affiliations
- PMID: 33501772
- DOI: 10.1111/irv.12842
Abstract
Background: Although the burden of influenza is well characterized, the burden of community-onset non-influenza respiratory viruses has not been systematically assessed. Understanding the severity and seasonality of non-influenza viruses, including human coronaviruses, will provide a better understanding of the overall disease burden from respiratory viruses that could better inform resource utilization for hospitals and highlight the value of preventative strategies, including vaccines.
Methods: From October 2017 to September 2019, a retrospective study was performed in a pre-defined catchment area to estimate the population-based incidence of community-onset respiratory viruses associated with hospitalization. Included patients were ≥18 years old, resided in New York City, were hospitalized for ≥24 hours, and had a respiratory virus detected within 3 calendar-days of admission. Disease burden was measured by hospital length of stay (LOS), intensive care unit (ICU) admissions, and in-hospital mortality and compared among those with laboratory-confirmed influenza versus those with laboratory-confirmed non-influenza viruses (human coronaviruses, parainfluenza viruses, respiratory syncytial virus, human metapneumovirus, and adenovirus).
Results: During the study period, 4232 eligible patients were identified of whom 50.9% were ≥65 years of age. For each virus, the population-based incidence was highest for those ≥80 years of age. When compared to those with influenza viruses detected, those with non-influenza respiratory viruses detected (combined) had higher population-based incidence, significantly more ICU admissions, and higher in-house mortality.
Conclusions: The burden of non-influenza respiratory viruses for hospitalized adults is substantial. Prevention and treatment strategies are needed for non-influenza respiratory viruses, particularly for older adults.
Keywords: adenovirus; human coronaviruses; influenza; parainfluenza viruses; respiratory syncytial virus.