tetano
Editor, Senior Moderator
Influenza Other Respir Viruses
. 2024 Jul;18(7):e13339.
doi: 10.1111/irv.13339. Antibody Response to Symptomatic Infection With SARS-CoV-2 Omicron Variant Viruses, December 2021-June 2022
Ryan Sandford[SUP] 1 2 3 [/SUP], Ruchi Yadav[SUP] 1 [/SUP], Emma K Noble[SUP] 1 2 [/SUP], Kelsey Sumner[SUP] 1 [/SUP], Devyani Joshi[SUP] 1 [/SUP], Sara Y Tartof[SUP] 4 5 [/SUP], Karen J Wernli[SUP] 6 [/SUP], Emily T Martin[SUP] 7 [/SUP], Manjusha Gaglani[SUP] 8 9 [/SUP], Richard K Zimmerman[SUP] 10 [/SUP], H Keipp Talbot[SUP] 11 [/SUP], Carlos G Grijalva[SUP] 11 [/SUP], Edward A Belongia[SUP] 12 [/SUP], Christina Carlson[SUP] 1 [/SUP], Melissa Coughlin[SUP] 1 [/SUP], Brendan Flannery[SUP] 1 [/SUP], Brad Pearce[SUP] 3 [/SUP], Eric Rogier[SUP] 1 [/SUP]
Affiliations
We describe humoral immune responses in 105 ambulatory patients with laboratory-confirmed SARS-CoV-2 Omicron variant infection. In dried blood spot (DBS) collected within 5 days of illness onset and during convalescence, we measured binding antibody (bAb) against ancestral spike protein receptor binding domain (RBD) and nucleocapsid (N) protein using a commercial multiplex bead assay. Geometric mean bAb concentrations against RBD increased by a factor of 2.5 from 1258 to 3189 units/mL and by a factor of 47 against N protein from 5.5 to 259 units/mL between acute illness and convalescence; lower concentrations were associated with greater geometric mean ratios. Paired DBS specimens may be used to evaluate humoral response to SARS-CoV-2 infection.
Keywords: COVID‐19; Omicron subvariants; SARS‐CoV‐2 infection; immune response.
. 2024 Jul;18(7):e13339.
doi: 10.1111/irv.13339. Antibody Response to Symptomatic Infection With SARS-CoV-2 Omicron Variant Viruses, December 2021-June 2022
Ryan Sandford[SUP] 1 2 3 [/SUP], Ruchi Yadav[SUP] 1 [/SUP], Emma K Noble[SUP] 1 2 [/SUP], Kelsey Sumner[SUP] 1 [/SUP], Devyani Joshi[SUP] 1 [/SUP], Sara Y Tartof[SUP] 4 5 [/SUP], Karen J Wernli[SUP] 6 [/SUP], Emily T Martin[SUP] 7 [/SUP], Manjusha Gaglani[SUP] 8 9 [/SUP], Richard K Zimmerman[SUP] 10 [/SUP], H Keipp Talbot[SUP] 11 [/SUP], Carlos G Grijalva[SUP] 11 [/SUP], Edward A Belongia[SUP] 12 [/SUP], Christina Carlson[SUP] 1 [/SUP], Melissa Coughlin[SUP] 1 [/SUP], Brendan Flannery[SUP] 1 [/SUP], Brad Pearce[SUP] 3 [/SUP], Eric Rogier[SUP] 1 [/SUP]
Affiliations
- PMID: 39012045
- PMCID: PMC11250392
- DOI: 10.1111/irv.13339
We describe humoral immune responses in 105 ambulatory patients with laboratory-confirmed SARS-CoV-2 Omicron variant infection. In dried blood spot (DBS) collected within 5 days of illness onset and during convalescence, we measured binding antibody (bAb) against ancestral spike protein receptor binding domain (RBD) and nucleocapsid (N) protein using a commercial multiplex bead assay. Geometric mean bAb concentrations against RBD increased by a factor of 2.5 from 1258 to 3189 units/mL and by a factor of 47 against N protein from 5.5 to 259 units/mL between acute illness and convalescence; lower concentrations were associated with greater geometric mean ratios. Paired DBS specimens may be used to evaluate humoral response to SARS-CoV-2 infection.
Keywords: COVID‐19; Omicron subvariants; SARS‐CoV‐2 infection; immune response.