tetano
Editor, Senior Moderator
Influenza Other Respir Viruses
. 2021 Jan 22.
doi: 10.1111/irv.12839. Online ahead of print.
Absence of association between 2019-20 influenza vaccination and COVID-19: Results of the European I-MOVE-COVID-19 primary care project, March-August 2020
Esther Kissling[SUP] 1 [/SUP], Mari?tte Hooiveld[SUP] 2 [/SUP], Mia Brytting[SUP] 3 [/SUP], Ana-Maria Vilcu[SUP] 4 [/SUP], Marit de Lange[SUP] 5 [/SUP], Iv?n Mart?nez-Baz[SUP] 6 [/SUP], Debbie Sigerson[SUP] 7 [/SUP], Theresa Enkirch[SUP] 3 [/SUP], Sylvie Belhillil[SUP] 8 [/SUP], Adam Meijer[SUP] 5 [/SUP], Jesus Castilla[SUP] 6 [/SUP], Naoma William[SUP] 7 [/SUP], AnnaSara Carnahan[SUP] 3 [/SUP], Alessandra Falchi[SUP] 9 [/SUP], Janneke Hendriksen[SUP] 2 [/SUP], Itziar Casado[SUP] 6 [/SUP], Josie Murray[SUP] 7 [/SUP], Vincent Enouf[SUP] 8 [/SUP], Frederika Dijkstra[SUP] 5 [/SUP], Diogo F P Marques[SUP] 1 7 [/SUP], Marta Valenciano[SUP] 1 [/SUP]
Affiliations
Background: Claims of influenza vaccination increasing COVID-19 risk are circulating. Within the I-MOVE-COVID-19 primary care multicentre study, we measured the association between 2019-20 influenza vaccination and COVID-19.
Methods: We conducted a multicentre test-negative case-control study at primary care level, in study sites in five European countries, from March to August 2020. Patients presenting with acute respiratory infection were swabbed, with demographic, 2019-20 influenza vaccination and clinical information documented. Using logistic regression, we measured the adjusted odds ratio (aOR), adjusting for study site and age, sex, calendar time, presence of chronic conditions. The main analysis included patients swabbed ≤7 days after onset from the three countries with <15% of missing influenza vaccination. In secondary analyses, we included five countries, using multiple imputation with chained equations to account for missing data.
Results: We included 257 COVID-19 cases and 1631 controls in the main analysis (three countries). The overall aOR between influenza vaccination and COVID-19 was 0.93 (95% CI: 0.66-1.32). The aOR was 0.92 (95% CI: 0.58-1.46) and 0.92 (95% CI: 0.51-1.67) among those aged 20-59 and ≥60 years, respectively. In secondary analyses, we included 6457 cases and 69 272 controls. The imputed aOR was 0.87 (95% CI: 0.79-0.95) among all ages and any delay between swab and symptom onset.
Conclusions: There was no evidence that COVID-19 cases were more likely to be vaccinated against influenza than controls. Influenza vaccination should be encouraged among target groups for vaccination. I-MOVE-COVID-19 will continue documenting influenza vaccination status in 2020-21, in order to learn about effects of recent influenza vaccination.
Keywords: COVID-19; SARS-CoV-2; case-control study; influenza vaccination; multicentre study; test-negative design.
. 2021 Jan 22.
doi: 10.1111/irv.12839. Online ahead of print.
Absence of association between 2019-20 influenza vaccination and COVID-19: Results of the European I-MOVE-COVID-19 primary care project, March-August 2020
Esther Kissling[SUP] 1 [/SUP], Mari?tte Hooiveld[SUP] 2 [/SUP], Mia Brytting[SUP] 3 [/SUP], Ana-Maria Vilcu[SUP] 4 [/SUP], Marit de Lange[SUP] 5 [/SUP], Iv?n Mart?nez-Baz[SUP] 6 [/SUP], Debbie Sigerson[SUP] 7 [/SUP], Theresa Enkirch[SUP] 3 [/SUP], Sylvie Belhillil[SUP] 8 [/SUP], Adam Meijer[SUP] 5 [/SUP], Jesus Castilla[SUP] 6 [/SUP], Naoma William[SUP] 7 [/SUP], AnnaSara Carnahan[SUP] 3 [/SUP], Alessandra Falchi[SUP] 9 [/SUP], Janneke Hendriksen[SUP] 2 [/SUP], Itziar Casado[SUP] 6 [/SUP], Josie Murray[SUP] 7 [/SUP], Vincent Enouf[SUP] 8 [/SUP], Frederika Dijkstra[SUP] 5 [/SUP], Diogo F P Marques[SUP] 1 7 [/SUP], Marta Valenciano[SUP] 1 [/SUP]
Affiliations
- PMID: 33481344
- DOI: 10.1111/irv.12839
Background: Claims of influenza vaccination increasing COVID-19 risk are circulating. Within the I-MOVE-COVID-19 primary care multicentre study, we measured the association between 2019-20 influenza vaccination and COVID-19.
Methods: We conducted a multicentre test-negative case-control study at primary care level, in study sites in five European countries, from March to August 2020. Patients presenting with acute respiratory infection were swabbed, with demographic, 2019-20 influenza vaccination and clinical information documented. Using logistic regression, we measured the adjusted odds ratio (aOR), adjusting for study site and age, sex, calendar time, presence of chronic conditions. The main analysis included patients swabbed ≤7 days after onset from the three countries with <15% of missing influenza vaccination. In secondary analyses, we included five countries, using multiple imputation with chained equations to account for missing data.
Results: We included 257 COVID-19 cases and 1631 controls in the main analysis (three countries). The overall aOR between influenza vaccination and COVID-19 was 0.93 (95% CI: 0.66-1.32). The aOR was 0.92 (95% CI: 0.58-1.46) and 0.92 (95% CI: 0.51-1.67) among those aged 20-59 and ≥60 years, respectively. In secondary analyses, we included 6457 cases and 69 272 controls. The imputed aOR was 0.87 (95% CI: 0.79-0.95) among all ages and any delay between swab and symptom onset.
Conclusions: There was no evidence that COVID-19 cases were more likely to be vaccinated against influenza than controls. Influenza vaccination should be encouraged among target groups for vaccination. I-MOVE-COVID-19 will continue documenting influenza vaccination status in 2020-21, in order to learn about effects of recent influenza vaccination.
Keywords: COVID-19; SARS-CoV-2; case-control study; influenza vaccination; multicentre study; test-negative design.