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Influenza or Meningococcal Immunization During Pregnancy and Mortality in Women and Infants: A Pooled Analysis of Randomized Controlled Trials

tetano

Editor, Senior Moderator
Pediatr Infect Dis J. 2020 May 1. doi: 10.1097/INF.0000000000002629. [Epub ahead of print]
Influenza or Meningococcal Immunization During Pregnancy and Mortality in Women and Infants: A Pooled Analysis of Randomized Controlled Trials.


Clark DR[SUP]1[/SUP], Omer SB[SUP]2,[/SUP][SUP]3,[/SUP][SUP]4[/SUP], Tapia MD[SUP]5,[/SUP][SUP]6[/SUP], Nunes MC[SUP]7,[/SUP][SUP]8[/SUP], Cutland CL[SUP]7,[/SUP][SUP]8[/SUP], Tielsch JM[SUP]9[/SUP], Wairagkar N[SUP]10,[/SUP][SUP]11[/SUP], Madhi SA[SUP]7,[/SUP][SUP]8[/SUP]; for BMGF Supported Maternal Influenza Immunization Trials Investigators Group.

Author information




Abstract

This analysis includes pooled data from 2 placebo-controlled maternal influenza immunization trials, with a separate analysis on a meningococcal conjugate vaccine-controlled maternal influenza immunization trial. Maternal influenza immunization was not associated with infant or maternal all-cause mortality in placebo-controlled trials. In the meningococcal conjugate vaccine-controlled trial, there were fewer deaths during low or any influenza circulation weeks among infants whose mothers received meningococcal conjugate vaccine. ClinicalTrials.gov identifiers: NCT01430689, NCT01034254 and NCT02465190.



PMID:32379201DOI:10.1097/INF.0000000000002629
 
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