tetano
Editor, Senior Moderator
Antivir Chem Chemother. 2012 Jul 26. doi: 10.3851/IMP2235. [Epub ahead of print]
Influenza Nucleoprotein: Promising Target for Antiviral Chemotherapy.
Cianci C, Gerritz SW, Deminie C, Krystal M.
Source
Bristol-Myers Squibb Research and Development, Wallingford, CT, USA. christopher.cianci@bms.com.
Abstract
In the search for new anti-influenza agents, the viral polymerase has often been targeted due to the involvement of multiple conserved proteins and their distinct activities. Polymerase associates with each of the eight singled-stranded negative-sense vRNA segments. These transcriptionally competent segments are coated with multiple copies of nucleoprotein (NP) to form the ribonucleoprotein (RNP). NP is an abundant essential protein, possessing operative and structural functions; participating in genome organization, nuclear trafficking, and RNA transcription and replication. This review examines NP structure and function; and explores NP as an emerging target for anti-influenza drug development, focusing on recently discovered aryl piperazine amide inhibitor chemotypes.
PMID:
22837443
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/22837443
Influenza Nucleoprotein: Promising Target for Antiviral Chemotherapy.
Cianci C, Gerritz SW, Deminie C, Krystal M.
Source
Bristol-Myers Squibb Research and Development, Wallingford, CT, USA. christopher.cianci@bms.com.
Abstract
In the search for new anti-influenza agents, the viral polymerase has often been targeted due to the involvement of multiple conserved proteins and their distinct activities. Polymerase associates with each of the eight singled-stranded negative-sense vRNA segments. These transcriptionally competent segments are coated with multiple copies of nucleoprotein (NP) to form the ribonucleoprotein (RNP). NP is an abundant essential protein, possessing operative and structural functions; participating in genome organization, nuclear trafficking, and RNA transcription and replication. This review examines NP structure and function; and explores NP as an emerging target for anti-influenza drug development, focusing on recently discovered aryl piperazine amide inhibitor chemotypes.
PMID:
22837443
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/22837443