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Influenza NS1 interacts with p53 and alters its binding to p53-responsive genes, in a promoter-dependent manner

tetano

tetano

Editor, Senior Moderator
FEBS Lett. 2013 Aug 13. pii: S0014-5793(13)00612-1. doi: 10.1016/j.febslet.2013.08.006. [Epub ahead of print]
Influenza NS1 interacts with p53 and alters its binding to p53-responsive genes, in a promoter-dependent manner.
Terrier O, Diederichs A, Dubois J, Cartet G, Lina B, Bourdon JC, Rosa-Calatrava M.
Source

Laboratoire de Virologie et Pathologie Humaine VirPath, Equipe VirCell, Universit? Claude Bernard Lyon 1, Universit? de Lyon, Lyon, France. Electronic address: olivier.terrier@univ-lyon1.fr.
Abstract

The interplay between influenza A viruses (IAV) and p53 has only been reported in a limited number of studies, mainly focusing on the antiviral role of p53. We investigated the impact of IAV infection on p53 stability and transcriptional activity. Our results indicate that IAV-induced stabilization of p53 only partially correlates with modulation of p53 transcriptional activity measured during infection. Moreover, we show that the viral non-structural protein 1 (NS1) is able to inhibit p53 transcriptional activity, in a promoter-dependent manner. Based on these data, we propose that NS1 may contribute to p53-mediated cell fate decision during IAV infection.
STRUCTURED SUMMARY OF PROTEIN INTERACTIONS:

p53physically interacts with NS1 by anti bait coimmunoprecipitation (View interaction).

Copyright ? 2013. Published by Elsevier B.V.
KEYWORDS:

Influenza virus, Non-structural protein NS1, Orthomyxoviridae, Transcription factor, p53

PMID:
23954291
[PubMed - as supplied by publisher]

http://www.ncbi.nlm.nih.gov/pubmed/23954291
 
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