tetano
Editor, Senior Moderator
Am J Physiol Lung Cell Mol Physiol. 2015 Sep 25:ajplung.00283.2015. doi: 10.1152/ajplung.00283.2015. [Epub ahead of print]
[h=1]Influenza lung injury: mechanisms and therapeutic opportunities.[/h] Gregory DJ[SUP]1[/SUP], Kobzik L[SUP]2[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] In this Perspective, we discuss some recent developments in the pathogenesis of acute lung injury following influenza infection, with an emphasis on promising therapeutic leads. Damage to the alveolar-capillary barrier has been quantified in mice, and agents have been identified that can help to preserve barrier integrity, such as Vasculotide, angiopoietin-like 4 neutralisation, and sphingosine 1-phosphate mimics. The roles of Fatty Acid Binding Protein 5, prostaglandin E2 and the interplay between IFNγ and STAT1 in epithelial signalling during infection have been addressed in vitro. Finally, we discuss the role of autophagy in inflammatory cytokine production and the viral lifecycle, and the opportunities this presents for intervention.
Copyright ? 2015, American Journal of Physiology - Lung Cellular and Molecular Physiology.
[h=4]KEYWORDS:[/h] acute lung injury; autophagy; influenza; signalling
PMID: 26408556 [PubMed - as supplied by publisher]
[h=1]Influenza lung injury: mechanisms and therapeutic opportunities.[/h] Gregory DJ[SUP]1[/SUP], Kobzik L[SUP]2[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] In this Perspective, we discuss some recent developments in the pathogenesis of acute lung injury following influenza infection, with an emphasis on promising therapeutic leads. Damage to the alveolar-capillary barrier has been quantified in mice, and agents have been identified that can help to preserve barrier integrity, such as Vasculotide, angiopoietin-like 4 neutralisation, and sphingosine 1-phosphate mimics. The roles of Fatty Acid Binding Protein 5, prostaglandin E2 and the interplay between IFNγ and STAT1 in epithelial signalling during infection have been addressed in vitro. Finally, we discuss the role of autophagy in inflammatory cytokine production and the viral lifecycle, and the opportunities this presents for intervention.
Copyright ? 2015, American Journal of Physiology - Lung Cellular and Molecular Physiology.
[h=4]KEYWORDS:[/h] acute lung injury; autophagy; influenza; signalling
PMID: 26408556 [PubMed - as supplied by publisher]