tetano
Editor, Senior Moderator
J Infect Dis. 2017 Aug 15;216(4):415-424. doi: 10.1093/infdis/jix268.
[h=1]Influenza-like Illness Incidence Is Not Reduced by Influenza Vaccination in a Cohort of Older Adults, Despite Effectively Reducing Laboratory-Confirmed Influenza Virus Infections.[/h] van Beek J[SUP]1[/SUP], Veenhoven RH[SUP]2[/SUP], Bruin JP[SUP]3[/SUP], van Boxtel RAJ[SUP]1[/SUP], de Lange MMA[SUP]1[/SUP], Meijer A[SUP]1[/SUP], Sanders EAM[SUP]1,[/SUP][SUP]4[/SUP], Rots NY[SUP]1[/SUP], Luytjes W[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]Background:[/h] Data on the relative contribution of influenza virus and other respiratory pathogens to respiratory infections in community-dwelling older adults (≥60 years) are needed.
[h=4]Methods:[/h] A prospective observational cohort study was performed in the Netherlands during 2 winters. Nasopharyngeal and oropharyngeal swabs were collected during influenza-like illness (ILI) episodes and from controls. Viruses and bacteria were identified by multiplex ligation-dependent probe amplification assay and conventional bacterial culture.
[h=4]Results:[/h] The ILI incidence in the consecutive seasons was 7.2% and 11.6%, and influenza virus caused 18.9% and 34.2% of ILI episodes. Potential pathogen were detected in 80% of the ILI events with influenza virus, coronaviruses, rhinoviruses, human metapneumovirus, respiratory syncytial virus, parainfluenza viruses, and Haemophilus influenzae being the most common. Influenza vaccination reduced influenza virus infection by 73% (95% confidence interval [CI], 26%-90%) and 51% (95% CI, 7%-74%) in ILI patients. However, ILI incidence was similar between vaccinated (7.6% and 10.8%) and nonvaccinated (4.2% and 11.4%) participants in 2011-2012 and 2012-2013, respectively (P > .05).
[h=4]Conclusions:[/h] Influenza virus is a frequent pathogen in older adults with ILI. Vaccination reduces the number of influenza virus infections but not the overall number of ILI episodes: other pathogens fill the gap. We suggest the existence of a pool of individuals with high susceptibility to respiratory infections.
[h=4]Clinical Trials Registration:[/h] NTR3386.
[h=4]KEYWORDS:[/h] influenza virus; influenza virus infection; influenza-like illness; older adults; vaccination
PMID: 28931240 DOI: 10.1093/infdis/jix268
[h=1]Influenza-like Illness Incidence Is Not Reduced by Influenza Vaccination in a Cohort of Older Adults, Despite Effectively Reducing Laboratory-Confirmed Influenza Virus Infections.[/h] van Beek J[SUP]1[/SUP], Veenhoven RH[SUP]2[/SUP], Bruin JP[SUP]3[/SUP], van Boxtel RAJ[SUP]1[/SUP], de Lange MMA[SUP]1[/SUP], Meijer A[SUP]1[/SUP], Sanders EAM[SUP]1,[/SUP][SUP]4[/SUP], Rots NY[SUP]1[/SUP], Luytjes W[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]Background:[/h] Data on the relative contribution of influenza virus and other respiratory pathogens to respiratory infections in community-dwelling older adults (≥60 years) are needed.
[h=4]Methods:[/h] A prospective observational cohort study was performed in the Netherlands during 2 winters. Nasopharyngeal and oropharyngeal swabs were collected during influenza-like illness (ILI) episodes and from controls. Viruses and bacteria were identified by multiplex ligation-dependent probe amplification assay and conventional bacterial culture.
[h=4]Results:[/h] The ILI incidence in the consecutive seasons was 7.2% and 11.6%, and influenza virus caused 18.9% and 34.2% of ILI episodes. Potential pathogen were detected in 80% of the ILI events with influenza virus, coronaviruses, rhinoviruses, human metapneumovirus, respiratory syncytial virus, parainfluenza viruses, and Haemophilus influenzae being the most common. Influenza vaccination reduced influenza virus infection by 73% (95% confidence interval [CI], 26%-90%) and 51% (95% CI, 7%-74%) in ILI patients. However, ILI incidence was similar between vaccinated (7.6% and 10.8%) and nonvaccinated (4.2% and 11.4%) participants in 2011-2012 and 2012-2013, respectively (P > .05).
[h=4]Conclusions:[/h] Influenza virus is a frequent pathogen in older adults with ILI. Vaccination reduces the number of influenza virus infections but not the overall number of ILI episodes: other pathogens fill the gap. We suggest the existence of a pool of individuals with high susceptibility to respiratory infections.
[h=4]Clinical Trials Registration:[/h] NTR3386.
[h=4]KEYWORDS:[/h] influenza virus; influenza virus infection; influenza-like illness; older adults; vaccination
PMID: 28931240 DOI: 10.1093/infdis/jix268