tetano
Editor, Senior Moderator
Enferm Infecc Microbiol Clin. 2015 May 26. pii: S0213-005X(15)00151-2. doi: 10.1016/j.eimc.2015.04.004. [Epub ahead of print]
[h=1]Influenza infection in the intensive care unit: Four years after the 2009 pandemic.[/h] P?rez-Carrasco M[SUP]1[/SUP], Lagunes L[SUP]2[/SUP], Ant?n A[SUP]3[/SUP], Gattarello S[SUP]2[/SUP], Laborda C[SUP]2[/SUP], Pumarola T[SUP]3[/SUP], Rello J[SUP]4[/SUP]; CRIPS investigators.
[h=3]Author information[/h]
[h=3]Abstract[/h] The role of influenza viruses in severe acute respiratory infection (SARI) in Intensive Care Units (ICU) remains unknown. The post-pandemic influenza A(H1N1)pdm09 period, in particular, has been poorly studied.
[h=4]OBJECTIVE:[/h] To identify influenza SARI patients in ICU, to assess the usefulness of the symptoms of influenza-like illness (ILI), and to compare the features of pandemic vs. post-pandemic influenza A(H1N1) pdm09 infection.
[h=4]METHODS:[/h] A prospective observational study with SARI patients admitted to ICU during the first three post-pandemic seasons. Patient demographics, characteristics and outcomes were recorded. An influenza epidemic period (IEP) was defined as >100 cases/100,000 inhabitants per week.
[h=4]RESULTS:[/h] One hundred sixty-three patients were diagnosed with SARI. ILI was present in 65 (39.9%) patients. Influenza infection was documented in 41 patients, 27 (41.5%) ILI patients, and 14 (14.3%) non-ILI patients, 27 of them during an IEP. Influenza A viruses were mainly responsible. Only five patients had influenza B virus infection, which were non-ILI during an IEP. SARI overall mortality was 22.1%, and 15% in influenza infection patients. Pandemic and post-pandemic influenza infection patients shared similar clinical features.
[h=4]CONCLUSIONS:[/h] During influenza epidemic periods, influenza infection screening should be considered in all SARI patients. Influenza SARI was mainly caused by subtype A(H1N1)pdm09 and A(H3N2) in post-pandemic seasons, and no differences were observed in ILI and mortality rate compared with a pandemic season.
Copyright ? 2015 Elsevier Espa?a, S.L.U. y Sociedad Espa?ola de Enfermedades Infecciosas y Microbiolog?a Cl?nica. All rights reserved.
[h=4]KEYWORDS:[/h] A (H1N1) pdm09; A(H1N1)pdm09; Acute respiratory failure; Enfermedad tipo gripe; Infecci?n respiratoria aguda grave; Influenza A virus; Influenza-like illness; Insuficiencia respiratoria aguda; Severe acute respiratory infection; Virus de la gripe A
PMID: 26025480 [PubMed - as supplied by publisher]
[h=1]Influenza infection in the intensive care unit: Four years after the 2009 pandemic.[/h] P?rez-Carrasco M[SUP]1[/SUP], Lagunes L[SUP]2[/SUP], Ant?n A[SUP]3[/SUP], Gattarello S[SUP]2[/SUP], Laborda C[SUP]2[/SUP], Pumarola T[SUP]3[/SUP], Rello J[SUP]4[/SUP]; CRIPS investigators.
[h=3]Author information[/h]
[h=3]Abstract[/h] The role of influenza viruses in severe acute respiratory infection (SARI) in Intensive Care Units (ICU) remains unknown. The post-pandemic influenza A(H1N1)pdm09 period, in particular, has been poorly studied.
[h=4]OBJECTIVE:[/h] To identify influenza SARI patients in ICU, to assess the usefulness of the symptoms of influenza-like illness (ILI), and to compare the features of pandemic vs. post-pandemic influenza A(H1N1) pdm09 infection.
[h=4]METHODS:[/h] A prospective observational study with SARI patients admitted to ICU during the first three post-pandemic seasons. Patient demographics, characteristics and outcomes were recorded. An influenza epidemic period (IEP) was defined as >100 cases/100,000 inhabitants per week.
[h=4]RESULTS:[/h] One hundred sixty-three patients were diagnosed with SARI. ILI was present in 65 (39.9%) patients. Influenza infection was documented in 41 patients, 27 (41.5%) ILI patients, and 14 (14.3%) non-ILI patients, 27 of them during an IEP. Influenza A viruses were mainly responsible. Only five patients had influenza B virus infection, which were non-ILI during an IEP. SARI overall mortality was 22.1%, and 15% in influenza infection patients. Pandemic and post-pandemic influenza infection patients shared similar clinical features.
[h=4]CONCLUSIONS:[/h] During influenza epidemic periods, influenza infection screening should be considered in all SARI patients. Influenza SARI was mainly caused by subtype A(H1N1)pdm09 and A(H3N2) in post-pandemic seasons, and no differences were observed in ILI and mortality rate compared with a pandemic season.
Copyright ? 2015 Elsevier Espa?a, S.L.U. y Sociedad Espa?ola de Enfermedades Infecciosas y Microbiolog?a Cl?nica. All rights reserved.
[h=4]KEYWORDS:[/h] A (H1N1) pdm09; A(H1N1)pdm09; Acute respiratory failure; Enfermedad tipo gripe; Infecci?n respiratoria aguda grave; Influenza A virus; Influenza-like illness; Insuficiencia respiratoria aguda; Severe acute respiratory infection; Virus de la gripe A
PMID: 26025480 [PubMed - as supplied by publisher]