tetano
Editor, Senior Moderator
BMC Infect Dis. 2019 May 14;19(1):415. doi: 10.1186/s12879-019-4017-0.
[h=1]Influenza epidemiology and influenza vaccine effectiveness during the 2015-2016 season: results from the Global Influenza Hospital Surveillance Network.[/h] Puig-Barber? J[SUP]1[/SUP], Mira-Iglesias A[SUP]2[/SUP], Burtseva E[SUP]3[/SUP], Cowling BJ[SUP]4[/SUP], Serhat U[SUP]5[/SUP], Ruiz-Palacios GM[SUP]6[/SUP], Launay O[SUP]7[/SUP], Kyncl J[SUP]8[/SUP], Koul P[SUP]9[/SUP], Siqueira MM[SUP]10[/SUP], Sominina A[SUP]11[/SUP]; Global Influenza Hospital Surveillance Network.
[h=3]Collaborators (49)[/h]
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] The Global Influenza Hospital Surveillance Network is an international platform whose primary objective is to study severe cases of influenza requiring hospitalization.
[h=4]METHODS:[/h] During the 2015-2016 influenza season, 11 sites in the Global Influenza Hospital Surveillance Network in nine countries (Russian Federation, Czech Republic, Turkey, France, China, Spain, Mexico, India, and Brazil) participated in a prospective, active-surveillance, hospital-based epidemiological study. Influenza infection was confirmed by reverse transcription-polymerase chain reaction. Influenza vaccine effectiveness (IVE) against laboratory-confirmed influenza was estimated using a test-negative approach.
[h=4]RESULTS:[/h] 9882 patients with laboratory results were included of which 2415 (24.4%) were positive for influenza, including 1415 (14.3%) for A(H1N1)pdm09, 235 (2.4%) for A(H3N2), 180 (1.8%) for A not subtyped, 45 (0.5%) for B/Yamagata-lineage, 532 (5.4%) for B/Victoria-lineage, and 33 (0.3%) for B not subtyped. Of included admissions, 39% were < 5 years of age and 67% had no underlying conditions. The odds of being admitted with influenza were higher among pregnant than non-pregnant women (odds ratio, 2.82 [95% confidence interval (CI), 1.90 to 4.19]). Adjusted IVE against influenza-related hospitalization was 16.3% (95% CI, 0.4 to 29.7). Among patients targeted for influenza vaccination, adjusted IVE against hospital admission with influenza was 16.2% (95% CI, - 3.6 to 32.2) overall, 23.0% (95% CI, - 3.3 to 42.6) against A(H1N1)pdm09, and - 25.6% (95% CI, - 86.3 to 15.4) against B/Victoria lineage.
[h=4]CONCLUSIONS:[/h] The 2015-2016 influenza season was dominated by A(H1N1)pdm09 and B/Victoria-lineage. Hospitalization with influenza often occurred in healthy and young individuals, and pregnant women were at increased risk of influenza-related hospitalization. Influenza vaccines provided low to moderate protection against hospitalization with influenza and no protection against the predominant circulating B lineage, highlighting the need for more effective and broader influenza vaccines.
[h=4]KEYWORDS:[/h] Epidemiological study; Hospitalization; Influenza; Surveillance; Vaccine; Virus
PMID: 31088481 PMCID: PMC6518734 DOI: 10.1186/s12879-019-4017-0
Free PMC Article
[h=1]Influenza epidemiology and influenza vaccine effectiveness during the 2015-2016 season: results from the Global Influenza Hospital Surveillance Network.[/h] Puig-Barber? J[SUP]1[/SUP], Mira-Iglesias A[SUP]2[/SUP], Burtseva E[SUP]3[/SUP], Cowling BJ[SUP]4[/SUP], Serhat U[SUP]5[/SUP], Ruiz-Palacios GM[SUP]6[/SUP], Launay O[SUP]7[/SUP], Kyncl J[SUP]8[/SUP], Koul P[SUP]9[/SUP], Siqueira MM[SUP]10[/SUP], Sominina A[SUP]11[/SUP]; Global Influenza Hospital Surveillance Network.
[h=3]Collaborators (49)[/h]
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] The Global Influenza Hospital Surveillance Network is an international platform whose primary objective is to study severe cases of influenza requiring hospitalization.
[h=4]METHODS:[/h] During the 2015-2016 influenza season, 11 sites in the Global Influenza Hospital Surveillance Network in nine countries (Russian Federation, Czech Republic, Turkey, France, China, Spain, Mexico, India, and Brazil) participated in a prospective, active-surveillance, hospital-based epidemiological study. Influenza infection was confirmed by reverse transcription-polymerase chain reaction. Influenza vaccine effectiveness (IVE) against laboratory-confirmed influenza was estimated using a test-negative approach.
[h=4]RESULTS:[/h] 9882 patients with laboratory results were included of which 2415 (24.4%) were positive for influenza, including 1415 (14.3%) for A(H1N1)pdm09, 235 (2.4%) for A(H3N2), 180 (1.8%) for A not subtyped, 45 (0.5%) for B/Yamagata-lineage, 532 (5.4%) for B/Victoria-lineage, and 33 (0.3%) for B not subtyped. Of included admissions, 39% were < 5 years of age and 67% had no underlying conditions. The odds of being admitted with influenza were higher among pregnant than non-pregnant women (odds ratio, 2.82 [95% confidence interval (CI), 1.90 to 4.19]). Adjusted IVE against influenza-related hospitalization was 16.3% (95% CI, 0.4 to 29.7). Among patients targeted for influenza vaccination, adjusted IVE against hospital admission with influenza was 16.2% (95% CI, - 3.6 to 32.2) overall, 23.0% (95% CI, - 3.3 to 42.6) against A(H1N1)pdm09, and - 25.6% (95% CI, - 86.3 to 15.4) against B/Victoria lineage.
[h=4]CONCLUSIONS:[/h] The 2015-2016 influenza season was dominated by A(H1N1)pdm09 and B/Victoria-lineage. Hospitalization with influenza often occurred in healthy and young individuals, and pregnant women were at increased risk of influenza-related hospitalization. Influenza vaccines provided low to moderate protection against hospitalization with influenza and no protection against the predominant circulating B lineage, highlighting the need for more effective and broader influenza vaccines.
[h=4]KEYWORDS:[/h] Epidemiological study; Hospitalization; Influenza; Surveillance; Vaccine; Virus
PMID: 31088481 PMCID: PMC6518734 DOI: 10.1186/s12879-019-4017-0
Free PMC Article