tetano
Editor, Senior Moderator
J Infect. 2014 Apr 3. pii: S0163-4453(14)00086-3. doi: 10.1016/j.jinf.2014.03.016. [Epub ahead of print]
Influenza C virus high seroprevalence rates observed in 3 different population groups.
Salez N1, M?lade J2, Pascalis H3, Aherfi S4, Dellagi K3, Charrel RN5, Carrat F6, de Lamballerie X5.
Author information
Abstract
The epidemiology of Influenza C virus (FLUCV) infections remains poorly characterised. Here, we have examined the age- and location-specific seroprevalence of antibodies against FLUCV in 1,441 sera from metropolitan continental France (Marseille), South-West Indian Ocean French territories (Reunion Island) and United-Kingdom (Edinburgh) using a combination of haemagglutination inhibition, virus neutralisation and ELISA assays. Our results show that immunity to FLUCV is common in all locations studied (global seroprevalence values >50%) and that the first immunising contacts generally occur early in life (i.e., in the 0-4 year-old age group). The latter item is further supported by the detection of FLUCV RNA by RT-PCR in naso-pharyngeal samples collected in patient attending the Emergency Room of the Public hospitals of Marseille, France with a large majority of children under 10 years-old: 17 (60.7%) in children ≤ 3yo, 10 (35.7%) in the 4-10yo age group and 1 (3.6%) in an adult (49yo). The temporal distribution of cases was atypical with regard to influenza (a large proportion of cases occurred in spring and summer) and the clinical presentation was diverse, including but being not limited to classical Influenza-like-Ilnesses. Altogether, our results indicate an intense circulation of FLUCV in the different study areas and an early occurrence of infection in human life. Flu C appears to be a widely under-diagnosed and under-studied human paediatric disease that obviously deserves further clinical and epidemiological characterisation.
Copyright ? 2014 The British Infection Association. Published by Elsevier Ltd. All rights reserved.
KEYWORDS:
ELISA, Influenza C, Virus Neutralisation Test, epidemiology, haemagglutination, real-time RT-PCR assay
PMID:
24704348
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/24704348
Influenza C virus high seroprevalence rates observed in 3 different population groups.
Salez N1, M?lade J2, Pascalis H3, Aherfi S4, Dellagi K3, Charrel RN5, Carrat F6, de Lamballerie X5.
Author information
Abstract
The epidemiology of Influenza C virus (FLUCV) infections remains poorly characterised. Here, we have examined the age- and location-specific seroprevalence of antibodies against FLUCV in 1,441 sera from metropolitan continental France (Marseille), South-West Indian Ocean French territories (Reunion Island) and United-Kingdom (Edinburgh) using a combination of haemagglutination inhibition, virus neutralisation and ELISA assays. Our results show that immunity to FLUCV is common in all locations studied (global seroprevalence values >50%) and that the first immunising contacts generally occur early in life (i.e., in the 0-4 year-old age group). The latter item is further supported by the detection of FLUCV RNA by RT-PCR in naso-pharyngeal samples collected in patient attending the Emergency Room of the Public hospitals of Marseille, France with a large majority of children under 10 years-old: 17 (60.7%) in children ≤ 3yo, 10 (35.7%) in the 4-10yo age group and 1 (3.6%) in an adult (49yo). The temporal distribution of cases was atypical with regard to influenza (a large proportion of cases occurred in spring and summer) and the clinical presentation was diverse, including but being not limited to classical Influenza-like-Ilnesses. Altogether, our results indicate an intense circulation of FLUCV in the different study areas and an early occurrence of infection in human life. Flu C appears to be a widely under-diagnosed and under-studied human paediatric disease that obviously deserves further clinical and epidemiological characterisation.
Copyright ? 2014 The British Infection Association. Published by Elsevier Ltd. All rights reserved.
KEYWORDS:
ELISA, Influenza C, Virus Neutralisation Test, epidemiology, haemagglutination, real-time RT-PCR assay
PMID:
24704348
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/24704348