tetano
Editor, Senior Moderator
Chem Commun (Camb). 2016 Jan 29. [Epub ahead of print]
[h=1]Influenza-binding sialylated polymer coated gold nanoparticles prepared via RAFT polymerization and reductive amination.[/h] Zhang Z[SUP]1[/SUP], Schepens B[SUP]2[/SUP], Nuhn L[SUP]1[/SUP], Saelens X[SUP]2[/SUP], Schotsaert M[SUP]2[/SUP], Callewaert N[SUP]2[/SUP], De Rycke R[SUP]2[/SUP], Zhang Q[SUP]3[/SUP], Moins S[SUP]4[/SUP], Benali S[SUP]4[/SUP], Mespouille L[SUP]4[/SUP], Hoogenboom R[SUP]3[/SUP], De Geest BG[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] We report on a straightforward strategy to fabricate bioactive glycosylated gold nanoparticles via a combination of RAFT polymerization, carbohydrate ligation through reductive amination and thiol-gold self-assembly. This approach is used for the design of gold nanoparticles decorated with the complex sialylated glycan Neu5Ac-α-2-6-Gal, and we demonstrate multivalent and specific recognition between the nanoparticles, lectins and hemagglutinin on the surface of the influenza virus.
PMID: 26823186 [PubMed - as supplied by publisher]
[h=1]Influenza-binding sialylated polymer coated gold nanoparticles prepared via RAFT polymerization and reductive amination.[/h] Zhang Z[SUP]1[/SUP], Schepens B[SUP]2[/SUP], Nuhn L[SUP]1[/SUP], Saelens X[SUP]2[/SUP], Schotsaert M[SUP]2[/SUP], Callewaert N[SUP]2[/SUP], De Rycke R[SUP]2[/SUP], Zhang Q[SUP]3[/SUP], Moins S[SUP]4[/SUP], Benali S[SUP]4[/SUP], Mespouille L[SUP]4[/SUP], Hoogenboom R[SUP]3[/SUP], De Geest BG[SUP]1[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] We report on a straightforward strategy to fabricate bioactive glycosylated gold nanoparticles via a combination of RAFT polymerization, carbohydrate ligation through reductive amination and thiol-gold self-assembly. This approach is used for the design of gold nanoparticles decorated with the complex sialylated glycan Neu5Ac-α-2-6-Gal, and we demonstrate multivalent and specific recognition between the nanoparticles, lectins and hemagglutinin on the surface of the influenza virus.
PMID: 26823186 [PubMed - as supplied by publisher]