tetano
Editor, Senior Moderator
J Med Virol. 2019 Dec 5. doi: 10.1002/jmv.25648. [Epub ahead of print] [h=1]Influenza B viral load analysis in patients with acute respiratory infection from a tertiary hospital in Brazil.[/h]
Rodrigues Guimar?es Alves V[SUP]1[/SUP], de Souza Luna LK[SUP]1[/SUP], Cruz JS[SUP]1[/SUP], Helena Perosa A[SUP]2[/SUP], Bellei N[SUP]1[/SUP].
[h=3]Author information[/h] 1 Clinical Virology Laboratory, Infectious Diseases Unit, Medicine Department, Universidade Federal de S?o Paulo, Escola Paulista de Medicina, S?o Paulo, SP, Brazil. 2 Central Laboratory, S?o Paulo Hospital, S?o Paulo, SP, Brazil.
[h=3]Abstract[/h] Currently, 2 genotypes of Influenza B viruses (IFB) are co-circulating in humans: Victoria (VIC) and Yamagata (YAM). Infection and viral load (VL) were analyzed in 105 genotyped IFB (59 VIC and 46 YAM) out of 3452 respiratory samples from immunodepressed (ID), immunocompetent (IC) including outpatients (OP) and hospitalized patients (HP) attended during 2001-2013 at S?o Paulo Hospital. VL (Log[SUB]10[/SUB] RNA copies/mL) calculation was possible in 78 samples (47 VIC, 31 YAM). The age group of 12-18 years presented the highest detection (14.13%). Rates of infection among groups were of 3.67% (IC), 1.68% (ID), 3.50% (OP), 0.6% (HP) and VLs varied from 2.8 to 10.13 with no difference regarding age, immune status, and disease severity. From 10 OP vaccinated against influenza, 8 (7 children, 1 ID) received a matching strain shot (VIC), and 2 a monovalent influenza A H1N1pdm09. Those patients presented a VL of 6.31?1.62 (mean?SD). IFB infection rates follow an age pattern, but VL seems not to be related to frequency or clinical outcome. IFB patients with previous immunization could point to some protection for VIC infections since there was no HP. Other immunological aspects such as lineage infection immune priming, previous infections, and vaccinations should be further investigated. This article is protected by copyright. All rights reserved.
This article is protected by copyright. All rights reserved.
[h=4]KEYWORDS:[/h] Influenza B virus; Victoria; Viral Load; Yamagata
PMID: 31803951 DOI: 10.1002/jmv.25648
Rodrigues Guimar?es Alves V[SUP]1[/SUP], de Souza Luna LK[SUP]1[/SUP], Cruz JS[SUP]1[/SUP], Helena Perosa A[SUP]2[/SUP], Bellei N[SUP]1[/SUP].
[h=3]Author information[/h] 1 Clinical Virology Laboratory, Infectious Diseases Unit, Medicine Department, Universidade Federal de S?o Paulo, Escola Paulista de Medicina, S?o Paulo, SP, Brazil. 2 Central Laboratory, S?o Paulo Hospital, S?o Paulo, SP, Brazil.
[h=3]Abstract[/h] Currently, 2 genotypes of Influenza B viruses (IFB) are co-circulating in humans: Victoria (VIC) and Yamagata (YAM). Infection and viral load (VL) were analyzed in 105 genotyped IFB (59 VIC and 46 YAM) out of 3452 respiratory samples from immunodepressed (ID), immunocompetent (IC) including outpatients (OP) and hospitalized patients (HP) attended during 2001-2013 at S?o Paulo Hospital. VL (Log[SUB]10[/SUB] RNA copies/mL) calculation was possible in 78 samples (47 VIC, 31 YAM). The age group of 12-18 years presented the highest detection (14.13%). Rates of infection among groups were of 3.67% (IC), 1.68% (ID), 3.50% (OP), 0.6% (HP) and VLs varied from 2.8 to 10.13 with no difference regarding age, immune status, and disease severity. From 10 OP vaccinated against influenza, 8 (7 children, 1 ID) received a matching strain shot (VIC), and 2 a monovalent influenza A H1N1pdm09. Those patients presented a VL of 6.31?1.62 (mean?SD). IFB infection rates follow an age pattern, but VL seems not to be related to frequency or clinical outcome. IFB patients with previous immunization could point to some protection for VIC infections since there was no HP. Other immunological aspects such as lineage infection immune priming, previous infections, and vaccinations should be further investigated. This article is protected by copyright. All rights reserved.
This article is protected by copyright. All rights reserved.
[h=4]KEYWORDS:[/h] Influenza B virus; Victoria; Viral Load; Yamagata
PMID: 31803951 DOI: 10.1002/jmv.25648