tetano
Editor, Senior Moderator
Vaccine. 2016 Feb 16. pii: S0264-410X(16)00094-3. doi: 10.1016/j.vaccine.2016.01.042. [Epub ahead of print]
[h=1]Influenza B vaccine lineage selection-An optimized trivalent vaccine.[/h] H?pping AM[SUP]1[/SUP], Fonville JM[SUP]2[/SUP], Russell CA[SUP]3[/SUP], James S[SUP]1[/SUP], Smith DJ[SUP]4[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Epidemics of seasonal influenza viruses cause considerable morbidity and mortality each year. Various types and subtypes of influenza circulate in humans and evolve continuously such that individuals at risk of serious complications need to be vaccinated annually to keep protection up to date with circulating viruses. The influenza vaccine in most parts of the world is a trivalent vaccine, including an antigenically representative virus of recently circulating influenza A/H3N2, A/H1N1, and influenza B viruses. However, since the 1970s influenza B has split into two antigenically distinct lineages, only one of which is represented in the annual trivalent vaccine at any time. We describe a lineage selection strategy that optimizes protection against influenza B using the standard trivalent vaccine as a potentially cost effective alternative to quadrivalent vaccines.
Copyright ? 2016 The Authors. Published by Elsevier Ltd.. All rights reserved.
[h=4]KEYWORDS:[/h] Decision tree; Hedging; Influenza B; Quadrivalent; Trivalent vaccine; Vaccine strain selection
PMID: 26896685 [PubMed - as supplied by publisher]
[h=1]Influenza B vaccine lineage selection-An optimized trivalent vaccine.[/h] H?pping AM[SUP]1[/SUP], Fonville JM[SUP]2[/SUP], Russell CA[SUP]3[/SUP], James S[SUP]1[/SUP], Smith DJ[SUP]4[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] Epidemics of seasonal influenza viruses cause considerable morbidity and mortality each year. Various types and subtypes of influenza circulate in humans and evolve continuously such that individuals at risk of serious complications need to be vaccinated annually to keep protection up to date with circulating viruses. The influenza vaccine in most parts of the world is a trivalent vaccine, including an antigenically representative virus of recently circulating influenza A/H3N2, A/H1N1, and influenza B viruses. However, since the 1970s influenza B has split into two antigenically distinct lineages, only one of which is represented in the annual trivalent vaccine at any time. We describe a lineage selection strategy that optimizes protection against influenza B using the standard trivalent vaccine as a potentially cost effective alternative to quadrivalent vaccines.
Copyright ? 2016 The Authors. Published by Elsevier Ltd.. All rights reserved.
[h=4]KEYWORDS:[/h] Decision tree; Hedging; Influenza B; Quadrivalent; Trivalent vaccine; Vaccine strain selection
PMID: 26896685 [PubMed - as supplied by publisher]