tetano
Editor, Senior Moderator
PLoS One. 2019 Jul 15;14(7):e0219012. doi: 10.1371/journal.pone.0219012. eCollection 2019.
[h=1]Influenza-associated pneumonia hospitalizations in Uganda, 2013-2016.[/h] Emukule GO[SUP]1[/SUP], Namagambo B[SUP]2[/SUP], Owor N[SUP]2[/SUP], Bakamutumaho B[SUP]2[/SUP], Kayiwa JT[SUP]2[/SUP], Namulondo J[SUP]2[/SUP], Byaruhanga T[SUP]2[/SUP], Tempia S[SUP]3,[/SUP][SUP]4[/SUP], Chaves SS[SUP]1,[/SUP][SUP]5[/SUP], Lutwama JJ[SUP]2[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] Influenza is an important contributor to acute respiratory illness, including pneumonia, and results in substantial morbidity and mortality globally. Understanding the local burden of influenza-associated severe disease can inform decisions on allocation of resources toward influenza control programs. Currently, there is no national influenza vaccination program in Uganda.
[h=4]METHODS:[/h] In this study, we used data on pneumonia hospitalizations that were collected and reported through the Health Management Information System (HMIS) of the Ministry of Health, Uganda, and the laboratory-confirmed influenza positivity data from severe acute respiratory illness (SARI) surveillance in three districts (Wakiso, Mbarara, and Tororo) to estimate the age-specific incidence of influenza-associated pneumonia hospitalizations from January 2013 through December 2016.
[h=4]RESULTS:[/h] The overall estimated mean annual rate of pneumonia hospitalizations in the three districts was 371 (95% confidence interval [CI] 323-434) per 100,000 persons, and was highest among children aged <5 years (1,524 [95% CI 1,286-1,849]) compared to persons aged ≥5 years (123 [95% CI 105-144]) per 100,000 persons. The estimated mean annual rate of influenza-associated pneumonia hospitalization was 34 (95% CI 23-48) per 100,000 persons (116 [95% CI 78-165] and 16 [95% CI 6-28] per 100,000 persons among children aged <5 years and those ≥5 years, respectively). Among children aged <5 years, the rate of hospitalized influenza-associated pneumonia was highest among those who were <2 years old (178 [95% CI 109-265] per 100,000 persons). Over the period of analysis, the estimated mean annual number of hospitalized influenza-associated pneumonia cases in the three districts ranged between 672 and 1,436, of which over 70% represent children aged <5 years.
[h=4]CONCLUSIONS:[/h] The burden of influenza-associated pneumonia hospitalizations was substantial in Uganda, and was highest among young children aged <5 years. Influenza vaccination may be considered, especially for very young children.
PMID: 31306466 DOI: 10.1371/journal.pone.0219012
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[h=1]Influenza-associated pneumonia hospitalizations in Uganda, 2013-2016.[/h] Emukule GO[SUP]1[/SUP], Namagambo B[SUP]2[/SUP], Owor N[SUP]2[/SUP], Bakamutumaho B[SUP]2[/SUP], Kayiwa JT[SUP]2[/SUP], Namulondo J[SUP]2[/SUP], Byaruhanga T[SUP]2[/SUP], Tempia S[SUP]3,[/SUP][SUP]4[/SUP], Chaves SS[SUP]1,[/SUP][SUP]5[/SUP], Lutwama JJ[SUP]2[/SUP].
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]BACKGROUND:[/h] Influenza is an important contributor to acute respiratory illness, including pneumonia, and results in substantial morbidity and mortality globally. Understanding the local burden of influenza-associated severe disease can inform decisions on allocation of resources toward influenza control programs. Currently, there is no national influenza vaccination program in Uganda.
[h=4]METHODS:[/h] In this study, we used data on pneumonia hospitalizations that were collected and reported through the Health Management Information System (HMIS) of the Ministry of Health, Uganda, and the laboratory-confirmed influenza positivity data from severe acute respiratory illness (SARI) surveillance in three districts (Wakiso, Mbarara, and Tororo) to estimate the age-specific incidence of influenza-associated pneumonia hospitalizations from January 2013 through December 2016.
[h=4]RESULTS:[/h] The overall estimated mean annual rate of pneumonia hospitalizations in the three districts was 371 (95% confidence interval [CI] 323-434) per 100,000 persons, and was highest among children aged <5 years (1,524 [95% CI 1,286-1,849]) compared to persons aged ≥5 years (123 [95% CI 105-144]) per 100,000 persons. The estimated mean annual rate of influenza-associated pneumonia hospitalization was 34 (95% CI 23-48) per 100,000 persons (116 [95% CI 78-165] and 16 [95% CI 6-28] per 100,000 persons among children aged <5 years and those ≥5 years, respectively). Among children aged <5 years, the rate of hospitalized influenza-associated pneumonia was highest among those who were <2 years old (178 [95% CI 109-265] per 100,000 persons). Over the period of analysis, the estimated mean annual number of hospitalized influenza-associated pneumonia cases in the three districts ranged between 672 and 1,436, of which over 70% represent children aged <5 years.
[h=4]CONCLUSIONS:[/h] The burden of influenza-associated pneumonia hospitalizations was substantial in Uganda, and was highest among young children aged <5 years. Influenza vaccination may be considered, especially for very young children.
PMID: 31306466 DOI: 10.1371/journal.pone.0219012
Free full text