tetano
Editor, Senior Moderator
J Virol. 2012 May 30. [Epub ahead of print]
Influenza A viruses control the expression of pro-viral human p53 isoforms, p53β and {Delta}133p53α
Terrier O, Marcel V, Cartet G, Lane DP, Lina B, Rosa-Calatrava M, Bourdon JC.
Source
Division of Medical Science, Centre for Oncology and Molecular Medicine, University of Dundee, Ninewells Hospital, Dundee, Scotland, UK.
Abstract
Previous studies have described the role of p53 isoforms, including p53β and Δ133p53α, in the modulation of activity of the full-length p53, which regulates the cell fate outcome. In the context of influenza infection, an interplay between influenza viruses and p53 has been described, p53 being involved in the antiviral response. However, the role of physiological p53 isoforms has never been explored in this context. Here, we demonstrate that p53 isoforms play a role in influenza A virus infection, using silencing and transient expression strategies in human lung epithelial cells. In addition, with the help of a panel of different influenza viruses from different subtypes, we also show that the infection differentially regulate the expression of p53β and Δ133p53α. Altogether, our results highlight the role of p53 isoforms in the viral cycle of influenza A viruses, p53β and Δ133p53α acting as regulators of viral production in a p53-dependent manner.
PMID:
22647703
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/22647703
Influenza A viruses control the expression of pro-viral human p53 isoforms, p53β and {Delta}133p53α
Terrier O, Marcel V, Cartet G, Lane DP, Lina B, Rosa-Calatrava M, Bourdon JC.
Source
Division of Medical Science, Centre for Oncology and Molecular Medicine, University of Dundee, Ninewells Hospital, Dundee, Scotland, UK.
Abstract
Previous studies have described the role of p53 isoforms, including p53β and Δ133p53α, in the modulation of activity of the full-length p53, which regulates the cell fate outcome. In the context of influenza infection, an interplay between influenza viruses and p53 has been described, p53 being involved in the antiviral response. However, the role of physiological p53 isoforms has never been explored in this context. Here, we demonstrate that p53 isoforms play a role in influenza A virus infection, using silencing and transient expression strategies in human lung epithelial cells. In addition, with the help of a panel of different influenza viruses from different subtypes, we also show that the infection differentially regulate the expression of p53β and Δ133p53α. Altogether, our results highlight the role of p53 isoforms in the viral cycle of influenza A viruses, p53β and Δ133p53α acting as regulators of viral production in a p53-dependent manner.
PMID:
22647703
[PubMed - as supplied by publisher]
http://www.ncbi.nlm.nih.gov/pubmed/22647703