tetano
Editor, Senior Moderator
Annu Rev Anim Biosci. 2019 Sep 3. doi: 10.1146/annurev-animal-021419-083756. [Epub ahead of print]
[h=1]Influenza A Virus Subpopulations and Their Implication in Pathogenesis and Vaccine Development.[/h] Ghorbani A[SUP]1[/SUP], Ngunjiri JM[SUP]1[/SUP], Lee CW[SUP]1[/SUP].
[h=3]Author information[/h] 1 Food Animal Health Research Program, Ohio Agricultural Research and Development Center, The Ohio State University, Wooster, Ohio 44691, USA; email: ghorbani.7@osu.edu, ngunjiri.1@osu.edu, lee.2854@osu.edu.
[h=3]Abstract[/h] The concept of influenza A virus (IAV) subpopulations emerged approximately 75 years ago, when Preben von Magnus described "incomplete" virus particles that interfere with the replication of infectious virus. It is now widely accepted that infectious particles constitute only a minor portion of biologically active IAV subpopulations. The IAV quasispecies is an extremely diverse swarm of biologically and genetically heterogeneous particle subpopulations that collectively influence the evolutionary fitness of the virus. This review summarizes the current knowledge of IAV subpopulations, focusing on their biologic and genomic diversity. It also discusses the potential roles IAV subpopulations play in virus pathogenesis and live attenuated influenza vaccine development. Expected final online publication date for the Annual Review of Animal Biosciences, Volume 8 is February 15, 2020. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.
PMID: 31479617 DOI: 10.1146/annurev-animal-021419-083756
[h=1]Influenza A Virus Subpopulations and Their Implication in Pathogenesis and Vaccine Development.[/h] Ghorbani A[SUP]1[/SUP], Ngunjiri JM[SUP]1[/SUP], Lee CW[SUP]1[/SUP].
[h=3]Author information[/h] 1 Food Animal Health Research Program, Ohio Agricultural Research and Development Center, The Ohio State University, Wooster, Ohio 44691, USA; email: ghorbani.7@osu.edu, ngunjiri.1@osu.edu, lee.2854@osu.edu.
[h=3]Abstract[/h] The concept of influenza A virus (IAV) subpopulations emerged approximately 75 years ago, when Preben von Magnus described "incomplete" virus particles that interfere with the replication of infectious virus. It is now widely accepted that infectious particles constitute only a minor portion of biologically active IAV subpopulations. The IAV quasispecies is an extremely diverse swarm of biologically and genetically heterogeneous particle subpopulations that collectively influence the evolutionary fitness of the virus. This review summarizes the current knowledge of IAV subpopulations, focusing on their biologic and genomic diversity. It also discusses the potential roles IAV subpopulations play in virus pathogenesis and live attenuated influenza vaccine development. Expected final online publication date for the Annual Review of Animal Biosciences, Volume 8 is February 15, 2020. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.
PMID: 31479617 DOI: 10.1146/annurev-animal-021419-083756