tetano
Editor, Senior Moderator
Diabetologia. 2015 Aug 8. [Epub ahead of print]
[h=1]Influenza A virus antibodies show no association with pancreatic islet autoantibodies in children genetically predisposed to type 1 diabetes.[/h] Kondrashova A[SUP]1[/SUP], Nurminen N, Patrikainen M, Huhtala H, Lehtonen J, Toppari J, Ilonen J, Simell OG, Veijola R, Knip M, Hy?ty H.
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]AIMS/HYPOTHESIS:[/h] Viral infections have long been considered potential triggers of beta cell autoimmunity and type 1 diabetes. Recent studies have suggested that influenza A virus might increase the risk of type 1 diabetes. The present study evaluates this risk association in prospectively observed children at the time when islet autoimmunity starts and autoantibodies are first detected.
[h=4]METHODS:[/h] IgG class antibodies to influenza A virus were analysed in 95 case children whose antibody screening test turned permanently positive for two or more islet autoantibodies and from 186 autoantibody-negative and non-diabetic control children who were matched for time of birth, sex, date of sampling and HLA-conferred risk of diabetes in the Finnish Type 1 Diabetes Prediction and Prevention (DIPP) study. Virus antibodies were measured from the first autoantibody-positive sample using an enzyme immunoassay. None of the children had been vaccinated against influenza A.
[h=4]RESULTS:[/h] The prevalence of influenza A virus antibodies did not differ between the case and control children (42% vs 38%; p = 0.392) and the median antibody levels were also comparable in the two groups (3.0 vs 3.8 enzyme immunoassay units). A similar result was obtained when case and control children were compared separately in subgroups according to different sex, age and HLA-DQ genotype. However, girls had higher antibody levels than boys among both case and control children (median antibody levels 9.0 vs 2.3 enzyme immunoassay units; p = 0.01).
[h=4]CONCLUSIONS/INTERPRETATION:[/h] Our results suggest that influenza A infections are not associated with the development of islet autoimmunity in young children with increased genetic susceptibility to type 1 diabetes.
PMID: 26253765 [PubMed - as supplied by publisher]
[h=1]Influenza A virus antibodies show no association with pancreatic islet autoantibodies in children genetically predisposed to type 1 diabetes.[/h] Kondrashova A[SUP]1[/SUP], Nurminen N, Patrikainen M, Huhtala H, Lehtonen J, Toppari J, Ilonen J, Simell OG, Veijola R, Knip M, Hy?ty H.
[h=3]Author information[/h]
[h=3]Abstract[/h] [h=4]AIMS/HYPOTHESIS:[/h] Viral infections have long been considered potential triggers of beta cell autoimmunity and type 1 diabetes. Recent studies have suggested that influenza A virus might increase the risk of type 1 diabetes. The present study evaluates this risk association in prospectively observed children at the time when islet autoimmunity starts and autoantibodies are first detected.
[h=4]METHODS:[/h] IgG class antibodies to influenza A virus were analysed in 95 case children whose antibody screening test turned permanently positive for two or more islet autoantibodies and from 186 autoantibody-negative and non-diabetic control children who were matched for time of birth, sex, date of sampling and HLA-conferred risk of diabetes in the Finnish Type 1 Diabetes Prediction and Prevention (DIPP) study. Virus antibodies were measured from the first autoantibody-positive sample using an enzyme immunoassay. None of the children had been vaccinated against influenza A.
[h=4]RESULTS:[/h] The prevalence of influenza A virus antibodies did not differ between the case and control children (42% vs 38%; p = 0.392) and the median antibody levels were also comparable in the two groups (3.0 vs 3.8 enzyme immunoassay units). A similar result was obtained when case and control children were compared separately in subgroups according to different sex, age and HLA-DQ genotype. However, girls had higher antibody levels than boys among both case and control children (median antibody levels 9.0 vs 2.3 enzyme immunoassay units; p = 0.01).
[h=4]CONCLUSIONS/INTERPRETATION:[/h] Our results suggest that influenza A infections are not associated with the development of islet autoimmunity in young children with increased genetic susceptibility to type 1 diabetes.
PMID: 26253765 [PubMed - as supplied by publisher]