tetano
Editor, Senior Moderator
Emerg Infect Dis. 2018 Apr 17;24(4). doi: 10.3201/eid2404.171995. [Epub ahead of print]
[h=1]Influenza A(H7N9) Virus Antibody Responses in Survivors 1 Year after Infection, China, 2017.[/h] Ma MJ, Liu C, Wu MN, Zhao T, Wang GL, Yang Y, Gu HJ, Cui PW, Pang YY, Tan YY, Hang H, Lin B, Qin JC, Fang LQ, Cao WC, Cheng LL.
[h=3]Abstract[/h] Avian influenza A(H7N9) virus has caused 5 epidemic waves in China since its emergence in 2013. We investigated the dynamic changes of antibody response to this virus over 1 year postinfection in 25 patients in Suzhou City, Jiangsu Province, China, who had laboratory-confirmed infections during the fifth epidemic wave, Oct 1, 2016-February 14, 2017. Most survivors had relatively robust antibody responses that decreased but remained detectable at 1 year. Antibody response was variable; several survivors had low or undetectable antibody titers. Hemagglutination inhibition titer was >1:40 for <40% of the survivors. Measured in vitro in infected mice, hemagglutination inhibition titer predicted serum protective ability. Our findings provide a helpful serologic guideline for identifying subclinical infections and for developing effective vaccines and therapeutics to counter H7N9 virus infections.
[h=4]KEYWORDS:[/h] China; H7N9 viruses; antibody response; cohort; influenza; influenza A(H7N9); persistence; serological; survivors; viruses
PMID: 29432091 DOI: 10.3201/eid2404.171995
[h=1]Influenza A(H7N9) Virus Antibody Responses in Survivors 1 Year after Infection, China, 2017.[/h] Ma MJ, Liu C, Wu MN, Zhao T, Wang GL, Yang Y, Gu HJ, Cui PW, Pang YY, Tan YY, Hang H, Lin B, Qin JC, Fang LQ, Cao WC, Cheng LL.
[h=3]Abstract[/h] Avian influenza A(H7N9) virus has caused 5 epidemic waves in China since its emergence in 2013. We investigated the dynamic changes of antibody response to this virus over 1 year postinfection in 25 patients in Suzhou City, Jiangsu Province, China, who had laboratory-confirmed infections during the fifth epidemic wave, Oct 1, 2016-February 14, 2017. Most survivors had relatively robust antibody responses that decreased but remained detectable at 1 year. Antibody response was variable; several survivors had low or undetectable antibody titers. Hemagglutination inhibition titer was >1:40 for <40% of the survivors. Measured in vitro in infected mice, hemagglutination inhibition titer predicted serum protective ability. Our findings provide a helpful serologic guideline for identifying subclinical infections and for developing effective vaccines and therapeutics to counter H7N9 virus infections.
[h=4]KEYWORDS:[/h] China; H7N9 viruses; antibody response; cohort; influenza; influenza A(H7N9); persistence; serological; survivors; viruses
PMID: 29432091 DOI: 10.3201/eid2404.171995